203401

Bleomycin Sulfate, Streptomyces verticillus

Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission.

• 同義詞: Bleomycin Sulfate, Streptomyces verticillus
• CAS號碼: 9041-93-4
• MDL號碼: MFCD00070310
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥90% (A₂ + B₂, HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white to off-white
• 溶解度: water: 20 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21?,22?,23?,24?,25?,29-,30+,34?,35?,36?,37+,38+,39-,40-,41?,42-,43-,53+,54-;/m0./s1
• InChI 密鑰: WUIABRMSWOKTOF-OCBSMOPSSA-N

描述

一般說明

A mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An antineoplastic agent capable of mimicking apoptosis. Useful in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.

Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.

生化／生理作用

Potency: 1.5-2.0 U/mg

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重構

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

其他說明

Tounekki, O., et al. 1994. Bull. Cancer 81, 1043.
Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
Ikeda, S., et al. 1991. Anal. Biochem.192, 96.
Hait, W.N., et al. 1990. Cancer Res.50, 6636.
Arkin, H., et al. 1989. Cancer Res.49, 6556.
Wu, J.C., et al. 1983. J. Biol. Chem.258, 4694.
Takita, T., et al. 1968. Antibiotics21, 79.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H340,H351,H361fd
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Carc. 2 - Muta. 1B - Repr. 2
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable