14-522-M

ABL (T315I) Protein, active

recombinant, expressed in baculovirus infected Sf21 cells

• 分類程式碼代碼: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

屬性

• product name: Abl (T315I) Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation. For use in Kinase Assays.
• 生物源: human
• 重組細胞: expressed in baculovirus infected Sf21 cells
• 分子量: M_w 121 kDa
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable (kinase)
• NCBI登錄號: NM_005157.3; NM_007313.2
• UniProt登錄號: P00519

描述

一般說明

N-terminal His6-tagged recombinant human Abl, residues 27-end containing the T315I mutation

Contains the gatekeeper mutation T315I in the ATP-binding domain. This mutation decreases the sensitivity to Gleevec by more than 200-fold as compared to the wild type sequence.

Product Source: Expressed by baculovirus in Sf21 insect cells

應用

Research Category
Metabolism

Inflammation & Immunology

Research Sub Category
Obesity

Metabolic Disorders

Osteoporosis

Arthritis

生化／生理作用

Protein Target: Abl

Target Sub-Family: TK

包裝

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-522M when ordering the 250 µg size.

品質

routinely evaluated by phosphorylation of Abltide

外觀

Ni²⁺/NTA-agarose

儲存和穩定性

6 months at -70°C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.