07-1225

Anti-PP5 Antibody

Upstate^®, from rabbit

• 同義詞: Protein phosphatase T, Serine/Threonine phosphatase, Serine/threonine-protein phosphatase 5, Protein phosphatase 5, catalytic subunit
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: mouse, human
• 製造商／商標名: Upstate^®
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG
• NCBI登錄號: NM_006247.2
• UniProt登錄號: P53041
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PPP5C(5536)

描述

一般說明

Protein phosphatase 5 (PP5) is a novel human protein serine/threonine phosphatase of molecular weight of 58 kDa. It is made up of a C-terminal phosphatase catalytic domain and an N-terminal domain, which has four repeats of 34 amino acids, three of which are tandemly arranged. The phosphatase domain contains all of the invariant motifs of the PP1/PP2A/PP2B gene family. However, it is not closely related to any other known member of this family of phosphatases. Thus it makes up a new subfamily of phosphatases. PP5 expressed in bacteria has been shown to dephosphorylate serine residues in proteins and is more sensitive than PP1 to the tumor promoter okadaic acid. PP5 appears to be localized to the nucleus where it is thought to play a roll in the regulation of RNA biogenesis and mitosis as part of a signaling pathway regulating cell cycle progression.

特異性

Recognizes Protein Phosphatase 5 (PP5).

免疫原

Synthetic peptide derived from the human protein phosphatase 5 protein.

應用

Detect PP5 using this Anti-PP5 Antibody validated for use in WB, IH(P).

Immunohistochemistry(paraffin):
Representative images from a previous lot.

Optimal Staining of PP5 Polyclonal Antibody: Human Testis

Research Category
Signaling

Research Sub Category
Kinases & Phosphatases

品質

Routinely evaluated by Western Blot on Jurkat lysates.

Western Blot Analysis: 1:500 dilution of this lot detected PP-5 on 10 μg of Jurkat lysates

標靶描述

58 kDa

聯結

Replaces: AB4092

外觀

Format: Purified

Purified rabbit polyclonal IgG in phosphate buffered saline with 0.08% sodium azide

儲存和穩定性

Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析報告

Control
Jurkat Cell Lysate, A549 and MCF-7 cell lysates.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable