04-893

Anti-JNK3/SAPK1b Antibody, clone C05T, rabbit monoclonal

culture supernatant, clone C05T, from rabbit

• 同義詞: JNK3 alpha protein kinase, MAP kinase, MAP kinase p49 3F12, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, c-Jun kinase 3, mitogen-activated protein kinase 10, stress activated protein kinase JNK3, stress activated protein kinase beta
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: culture supernatant
• 抗體產品種類: primary antibodies
• 無性繁殖: C05T, monoclonal
• 物種活性: rat, human
• 技術: western blot: suitable
• 同型: IgG
• NCBI登錄號: NM_002753.2
• UniProt登錄號: P49187
• 運輸包裝: dry ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MAPK10(5602) ; rat ... Mapk10(25272)

描述

一般說明

The stress-activated protein kinase 1 family is also referred to as the jun N-terminal kinase family, in light of the substrate preference of these serine/threonine kinases. The SAPK family shares 42-45% identity in the kinase domains with the MAPK family, and the SAPKs are activated by phosphorylation of a threonine and tyrosine by MKK4 and SKK4, just as the MAP kinases are phosphorylated on a threonine and tyrosine by MEK1 and MEK2. By contrast to the mitogen-activated kinases, the stress-activated kinases are only weakly activated by mitogenic stimuli, but potently activated by stress stimuli, such as inflammatory cytokines, ischemia, chemotherapeutic agents and irradiation.
The JNK/SAPK1 kinases, like the other MAPK-like kinases, are thought to phosphorylate multiple substrates and regulate many processes, including proliferation (in some cell types) and apoptosis. The SAPK2/3 family is most widely referred to as the p38 family. These kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. The activating kinases of SAPK2/3 are SKK2/MEK3 for SAPK2a and 2b, and MKK6 for SAPK3. The targets of the SAPK2/3 family include the MAPKAP kinases 2 and 3/3pK. In addition, SKK4 is related to this family, exhibiting 60% identity, and is activated by MKK6.

特異性

Recognizes JNK3/SAPK1b. Does not cross react with JNK1 or JNK2.

免疫原

GST fusion protein corresponding to full-length rat JNK3/ SAPK1b

應用

Detect JNK3/SAPK1b using this Anti-JNK3/SAPK1b Antibody, clone C05T validated for use in WB.

Research Category
Signaling

Research Sub Category
Kinases & Phosphatases

Western Blot Analysis: A 1:500-1:2,000 dilution of this lot detected JNK3 in RIPA lysates from A431 cells.

品質

Routinely evaluated by western blot on RIPA lysates from A431 cells.

標靶描述

46-54kDa

聯結

Replaces: 05-893

外觀

Cultured supernantant in 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at -20°C from date of receipt.

分析報告

Control
RIPA cell lysates from A431 cells.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable