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重要文件

H-902

Supelco

α-酮康唑 溶液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

經驗公式(希爾表示法):
C18H13ClFN3O
CAS號碼:
分子量::
341.77
EC號碼:
分類程式碼代碼:
41116107
NACRES:
NA.24
暫時無法取得訂價和供貨情況

等級

certified reference material

品質等級

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商/商標名

Cerilliant®

濃度

100 μg/mL in methanol

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing

形式

single component solution

儲存溫度

−20°C

SMILES 字串

OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12

InChI

1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2

InChI 密鑰

QHSMEGADRFZVNE-UHFFFAOYSA-N

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一般說明

α-羟基咪达唑仑是苯二氮咪达唑仑在尿液和血液中的活性主要代谢产物。咪达唑仑以Dormicum、Hypnovel®和Versed商品名销售,并已作为治疗失眠和惊厥的镇静剂和治疗方法。该认证的加标溶液®适合用作校准品或对照品中的原材料,用于从法医分析和临床毒理学到尿液药物测试的各种LC/MS或GC/MS应用。

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Hypnovel is a registered trademark of Hoffman-LaRoche & Co. AG
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

49.5 °F - closed cup

閃點(°C)

9.7 °C - closed cup


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分析證明 (COA)

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Cyrille Marvalin et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(3), 285-293 (2011-10-26)
Midazolam, a potent benzodiazepine derivative and a typical substrate of CYP3A4/3A5, is essentially metabolized in human into 1'-hydroxymidazolam, then eliminated as the corresponding phase II metabolite, the 1'-O-β-D-glucuronide derivative. A high yield alternative to the current multistep synthesis of 1'-hydroxymidazolam
Toshiyuki Iwasaki et al.
Pediatrics international : official journal of the Japan Pediatric Society, 52(4), 513-519 (2009-12-17)
The aim of the present study was to determine an index to evaluate the efficacy and safety of midazolam (MDZ) to treat status epilepticus (SE). An original system was therefore developed to measure blood concentrations of MDZ and 1-hydroxymidazolam (1-OHMDZ)
Ruut Kaartama et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(19), 1668-1676 (2011-05-03)
A sensitive and selective gas chromatographic mass spectrometric method for the determination of midazolam and its biologically active metabolite, 1-hydroxymidazolam, in rabbit plasma has been developed and validated. Sample preparation includes mixed-mode solid-phase extraction and derivatization with silylating reagents. Midazolam-d4
High-throughput analysis of in vitro cytochrome p450 inhibition samples using mass spectrometry coupled with an integrated liquid chromatography/autosampler system.
Ann Brown et al.
Rapid communications in mass spectrometry : RCM, 24(8), 1207-1210 (2010-03-20)
Kai-Ming Duan et al.
Journal of clinical pharmacology, 52(6), 940-946 (2011-06-18)
The aims of this study were to investigate the effect of quercetin on CYP3A activity in vivo. An open, randomized, 2-period crossover experiment was performed in 18 healthy male volunteers. Genotyped data were available from a total of 165 participants.

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