D-034

右啡烷 酒石酸酯 溶液

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 經驗公式（希爾表示法）: C₂₁H₂₉NO₇
• CAS號碼: 143-98-6
• 分子量：: 407.46
• EC號碼: 200-659-6
• MDL號碼: MFCD00151495
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329798600
• NACRES: NA.24

屬性

• 等級: certified reference material
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 1.0 mg/mL in methanol (as free base)
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: forensics and toxicology
• 格式: single component solution
• 儲存溫度: −20°C
• SMILES 字串: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34
• InChI: 1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m11/s1
• InChI 密鑰: RWTWIZDKEIWLKQ-XCPWPWHNSA-N

描述

一般說明

Snap-N-Spike^®参比溶液适用于临床毒理学、法医分析、P450试验或药物研究的LC/MS或GC/MS应用。右啡烷是血液中右美沙芬的主要代谢产物。右美沙芬是许多非处方感冒和咳嗽中的活性成分，被娱乐性地用作致幻剂，其作用类似于氯胺酮和苯环利定（PCP）。

應用

• Anti-Persister Activity Against Borrelia burgdorferi: Dextrorphan tartrate was evaluated for its anti-persister activity against Borrelia burgdorferi, demonstrating potential as an effective agent in the treatment of persistent Lyme disease infections. This research underscores its pharmacodynamic relevance and encourages further exploration in neuropharmacological contexts (Feng et al., 2015).


• High-Performance Liquid Chromatography in Pharmacokinetics: Dextrorphan tartrate was used in a sensitive assay involving high-performance liquid chromatography for the detection of metoprolol and its major metabolite in human plasma. This method highlights its importance as an analytical standard in pharmacokinetic studies, aiding in the understanding of drug metabolism and disposition (Mistry et al., 1998).


• Opioid Receptor Binding: The interaction of dextrorphan tartrate with opioid receptors was examined, showing that it binds to opioid receptors in guinea-pig brain membranes and acts as an antagonist in myenteric plexus. This research supports its utility in opioid receptor studies, particularly in examining opioid antagonistic properties (Goldstein & Naidu, 1990).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup