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850186P

Avanti

08:0 PI(3,4,5)P3

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium salt), powder

同義詞:

PIP3[3′,4′,5′](8:0/8:0); 110667

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About This Item

經驗公式（希爾表示法）:
C25H62N4O22P4
CAS號碼:
852043-38-0
分子量：:
894.67
MDL號碼:
MFCD22416577
分類程式碼代碼:
51191904
NACRES:
NA.25
暫時無法取得訂價和供貨情況

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 100 μg (with stopper and crimp cap (850186P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850186P-500ug))

製造商／商標名

Avanti Research™ - A Croda Brand 850186P

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+].[NH4+]

一般說明

磷脂酰肌醇3，4，5-三磷酸（PI（3，4，5）P3）是一种不太丰富的脂质。[1]
肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。

應用

08:0 PI（3，4，5）P3可用作评估磷酸肌醇3-激酶活性的对照化合物。[2]

生化／生理作用

磷脂酰肌醇3，4，5-三磷酸（PI（3，4，5）P3），脂质第二信使[3][1]可以调节突触活性。[1]

包裝

带塞子和压接盖的2 mL棕色血清瓶（850186P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850186P-500ug）

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

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分析證明 (COA)

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Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85 alpha-p110 alpha fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors
Sinnamon RH, et al.
Protein Expression and Purification, 73(2), 167-176 (2010)
Thang Manh Khuong et al.
Neuron, 77(6), 1097-1108 (2013-03-26)
PI(3,4,5)P3 is a low-abundance lipid thought to play a role in the regulation of synaptic activity; however, the mechanism remains obscure. We have constructed novel split Venus-based probes and used superresolution imaging to localize PI(3,4,5)P3 at Drosophila larval neuromuscular synapses. We find
Kewei Ma et al.
Cellular signalling, 20(4), 684-694 (2008-02-06)
The PI3K-PKB pathway is an important and widely studied pathway in cell signaling. The enzyme activity of PI3K produces D-3 phosphoinositides, including the lipid second messengers PI(3,4,5)P3 and PI(3,4)P2. PI(3,4,5)P3 has been deemed to be the most important second messenger
Rays H Y Jiang et al.
Cell host & microbe, 11(2), 99-100 (2012-02-22)
Survival of blood stage malaria parasites requires extensive host cell remodeling, which is facilitated by secretion of parasite proteins via a dedicated protein export pathway. In a recent Cell paper, Bhattacharjee et al., (2012) describe PI(3)P binding as one of the
Sulochanadevi Baskaran et al.
Molecular cell, 47(3), 339-348 (2012-06-19)
Macroautophagy is essential to cell survival during starvation and proceeds by the growth of a double-membraned phagophore, which engulfs cytosol and other substrates. The synthesis and recognition of the lipid phosphatidylinositol 3-phosphate, PI(3)P, is essential for autophagy. The key autophagic
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