化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 50 μg (810230P-50ug)
製造商／商標名
Avanti Research™ - A Croda Brand 810230P
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
生化／生理作用
Safingol, a competitive inhibitor of sphingosine kinase 1, exhibits anticancer activity. It is known to increase antitumor activity of cisplatin in xenograft experiments.[3]
包裝
5 mL Amber Glass Screw Cap Vial (810230P-50ug)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Mark A Dickson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 17(8), 2484-2492 (2011-01-25)
Sphingosine 1-phosphate (S1P) is an important mediator of cancer cell growth and proliferation. Production of S1P is catalyzed by sphingosine kinase 1 (SphK). Safingol, (l-threo-dihydrosphingosine) is a putative inhibitor of SphK. We conducted a phase I trial of safingol (S)
Jesse Coward et al.
Autophagy, 5(2), 184-193 (2008-12-23)
Safingol, the synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine, is an inhibitor of protein kinase C and sphingosine kinase in vitro, and in some cell types has been implicated in ceramide generation and induction of apoptosis. Utilizing electron microscopy, acridine orange
Synthesis of threo-beta-aminoalcohols from aminoaldehydes via chelation-controlled additions. Total synthesis of l-threo sphingosine and safingol
Jung ME and Yi SW
Tetrahedron Letters, 53(32), 4216-4220 (2012)
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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