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重要文件

810175P

Avanti

18:1-06:0 NBD PA

Avanti Research™ - A Croda Brand

同義詞:

1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphate (ammonium salt)

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About This Item

經驗公式（希爾表示法）:
C33H56N5O11P
CAS號碼:
474942-97-7
分子量：:
729.80
MDL號碼:
MFCD00870345
分類程式碼代碼:
12352211
NACRES:
NA.25
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化驗

>99% (TLC)

形狀

powder

包裝

pkg of 5 × 2 mg (810175P-10mg)

製造商／商標名

Avanti Research™ - A Croda Brand

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

Phosphatidic acid (PA) is an amphipathic lipid containing a polar head group and two long hydrophobic acyl chains. PA is an anionic and a membrane structural lipid. It acts as a parent compound for more complex membrane phospholipids.[1]

應用

18:1-06:0 NBD PA may be used for study the effects of NBD-PA induced vesiculation on epidermal growth factor receptor (EGFR) endocytosis in mammalian cells[2] and the co-localization of fluorescently-labeled poly(A)-specific ribonuclease (PARN) with the NBD-tagged PA that outlines the close proximity phospholipase D (PLD2) and PARN.[3]

生化／生理作用

Phosphatidic acid (PA) is a bioactive lipid and a secondary messenger.[4] PA reacts with water and other phospholipids to produce lipid bilayers and multicomponent bilayers respectively.[1]

包裝

5 mL Amber Glass Screw Cap Vial (810175P-10mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

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分析證明 (COA)

Lot/Batch Number

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Bioactive Lipids
An Introduction to Biological Membranes, , number=(, pages=), 453-478 (2016)
Lipid second messengers and Receptors
Encyclopedia of Endocrine Diseases, 77(3), 329-334 (2004)
Taylor E Miller et al.
Biology open, 6(2), 176-186 (2016-12-25)
The removal of mRNA transcript poly(A) tails by 3'→5' exonucleases is the rate-limiting step in mRNA decay in eukaryotes. Known cellular deadenylases are the CCR4-NOT and PAN complexes, and poly(A)-specific ribonuclease (PARN). The physiological roles and regulation for PARN is
Interaction of amyloid beta-protein with anionic phospholipids: possible involvement of Lys28 and C-terminus aliphatic amino acids
Chauhan A, et al.
Neurochemical Research, 25(3), 423-429 (2000)
A Chauhan et al.
Neurochemical research, 25(3), 423-429 (2000-04-13)
Fibrillar amyloid beta-protein (Abeta) is the major protein of amyloid plaques in the brains of patients with Alzheimer's disease (AD). The mechanism by which normally produced soluble Abeta gets fibrillized in AD is not clear. We studied the effect of
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