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Merck
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文件

800730P

Avanti

N-16:0 L-Serine MeEster

N-palmitoyl L-serine methyl ester, powder

同義詞:

1-hexadecanoyl-L-serine methyl ester; (S)-methyl-3-hydroxy-2-hexadecanamidopropanoate; (S)-methyl-3-hydroxy-2-palmitamidopropanoate ; 110830

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About This Item

經驗公式（希爾表示法）:
C20H39NO4
CAS號碼:
79876-27-0
分子量：:
357.53
分類程式碼代碼:
12352211
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 5 mg (800730P-5mg)

製造商／商標名

Avanti Research™ - A Croda Brand 800730P

脂質類型

phosphoglycerides
bioactive lipids

運輸包裝

dry ice

儲存溫度

−20°C

相關類別

一般說明

N-palmitoyl-L-serine methyl ester is an amino acid amphiphile. It is synthesized synthetically from N-succinimidyl palmitate, L-serine methyl ester hydrochloride and triethyl amine.

生化／生理作用

N-palmitoyl-L-serine methyl ester hydrochloride is used for the synthesis of N-palmitoyl-O-phosphocholine serine (PPCS), which is a prime lipid biomarker in Niemann-Pick disease type C1. It is also used for preparation of amino acid based gelators for drug delivery studies.

包裝

5 mL Amber Glass Screw Cap Vial (800730P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

分析證明 (COA)

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N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease
Sidhu R, et al.
Journal of Lipid Research, 60(8), 1410-1424 (2019)
D Vollhardt et al.
Physical chemistry chemical physics : PCCP, 21(1), 96-103 (2018-12-07)
The monolayers of N-alkanoyl substituted threonine amphiphiles, similar to those of other N-alkanoyl-substituted amino acid amphiphiles, point to substantial differences in the main characteristics compared to usual amphiphilic monolayers. π-A measurements of the enantiomeric and racemic forms of N-alkanoyl-substituted threonine
Special features of monolayer characteristics of N-alkanoyl substituted threonine amphiphiles
Vollhardt D, et al.
Physical Chemistry Chemical Physics, 21(1), 96-103 (2019)
Rohini Sidhu et al.
Journal of lipid research, 60(8), 1410-1424 (2019-06-16)
Niemann-Pick disease type C1 (NPC1) is a fatal, neurodegenerative, cholesterol storage disorder. With new therapeutics in clinical trials, there is an urgency to improve diagnostics and monitor therapeutic efficacy with biomarkers. In this study, we sought to define the structure
Systematic modifications of amino acid-based organogelators for the investigation of structure-property correlations in drug delivery system
Hu B, et al.
International Journal of Pharmaceutics, 547(1-2), 637-647 (2018)
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