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800725P

Avanti

N-P Tyrosine PA

Avanti Research - A Croda Brand 800725P, powder

同義詞:

N-palmitoyl-tyrosine phosphoric acid (ammonium salt)

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About This Item

經驗公式(希爾表示法):
C25H48N3O7P
CAS號碼:
分子量::
533.64
MDL號碼:
分類程式碼代碼:
12352211
NACRES:
NA.25
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化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (800725P-1mg)

製造商/商標名

Avanti Research - A Croda Brand 800725P

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid are competitive inhibitors of the LPA receptor in Xenopus oocytes.[1][2] However, in mammalian cells, N-palmitoyl-tyrosine phosphoric acid may act as an agonist for the LPA receptor.[3] LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors.[1][2][4][3] LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.[1]

包裝

5 mL Amber Glass Screw Cap Vial (800725P-1mg)

準備報告

Product use: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid can be used for cell studies.[3] dissolved these lipids in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells.[3] In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.[2]

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


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分析證明 (COA)

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Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
An, S
Molecular Pharmacology, 54, 881-888 (1998)
Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.
Neidlinger, N.A, et. al.
The Journal of Biological Chemistry, 281, 775-781 (2006)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids
Bittman, R, et. al.
Journal of Lipid Research, 37, 391-398 (1996)
N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors
Liliom, K
Molecular Pharmacology, 50, 616-623 (1996)
S An et al.
Molecular pharmacology, 54(5), 881-888 (1998-11-06)
Mobilization of intracellular Ca2+ is a critical cellular response to lysophosphatidic acid (LPA) in many cell types. Recent identification of endothelial differentiation gene (Edg) 2 and Edg4 as subtypes of G protein-coupled receptors for LPA allowed examination of the Ca2+

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