700026P

3β-hydroxy-7-oxo-5-cholestenoic acid

Avanti Research^™ - A Croda Brand

• 同義詞: (25R)-cholest-5-en-26-oic acid, 3β-hydroxy-7-oxo
• 經驗公式（希爾表示法）: C₂₇H₄₂O₄
• CAS號碼: 1246298-64-5
• 分子量：: 430.62
• MDL號碼: MFCD19704918
• 分類程式碼代碼: 12352211
• NACRES: NA.25

屬性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 5 mg (700026P-5mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand
• 運輸包裝: dry ice
• 儲存溫度: −20°C

描述

一般說明

Cholestenoic acids are cholesterol metabolic intermediates and precursors to bile acids.[1] 3β-hydroxy-7-oxo-5-cholestenoic acid is synthesized from 7β-hydroxycholesterol.[2] The enzymes for synthesis of cholestenoic acids are majorly present in the central nervous system (CNS) of mammals.[1] 3β-hydroxy-7-oxo-5-cholestenoic acid (3βH,7O-CA) is also synthesized from 26-hydroxy-7-oxocholesterol by the action of the enzyme cytochrome P450 family 27 subfamily A member 1 sterol 27-hydroxylase (CYP27A1).[3]

生化／生理作用

3β-hydroxy-7-oxocholest-5-en-26-oic acid (3βH,7O-CA) acts as a ligand for liver X receptors (LXR) and activates them at micromolar concentration. 3βH,7O-CA favors the islet-1⁺ cells synthesis and islet-1–GFP expression.[1] 3βH,7O-CA also mediates oculomotor neurons maturation and its conversion to 3β,7β-dihydroxycholest-5-en-(25S)26-oic acid (3β,7β-diHCA) is catalyzed by the enzyme hydroxysteroid 11-β dehydrogenase.[4]

包裝

5 mL Amber Glass Screw Cap Vial (700026P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids