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重要文件

P8533

Sigma-Aldrich

焦磷酸三丁基铵

同義詞:

N,N-dibutyl-1-butanamine diphosphate

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.22
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形狀

powder

儲存溫度

−20°C

SMILES 字串

OP(O)(=O)OP(O)(O)=O.CCCCN(CCCC)CCCC.CCCCN(CCCC)CCCC

InChI

1S/2C12H27N.H4O7P2/c2*1-4-7-10-13(11-8-5-2)12-9-6-3;1-8(2,3)7-9(4,5)6/h2*4-12H2,1-3H3;(H2,1,2,3)(H2,4,5,6)

InChI 密鑰

WRMXOVHLRUVREB-UHFFFAOYSA-N

一般說明

三丁基焦磷酸铵是一种磷酸化试剂,用于合成修饰dNTP(脱氧核苷三磷酸),这是生成DNA、RNA、功能化核酸的基本嵌段。[1]

應用

三丁基焦磷酸铵可用作磷酸化试剂以:
  • 与1, 1′-羰基二咪唑合成S′-脱氧-S′-甲基膦酸二甲酯。
  • 合成克量级碱基修饰核糖核苷-5′-O-三磷酸盐。
  • 采用一锅法化学合成2′-脱氧核糖核苷-5′-三磷酸盐,进而起到更好的保护作用。
可作为如下过程的反应物:
  • 3′-脱氧-apio-核酸双链体的酶促合成
  • 脱氧核苷S-甲基膦酸的合成
  • 荧光非核苷酸ATP类似物N-甲基蒽基酰胺基乙基三磷酸酯的制备

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

A facile and effective synthesis of dinucleotide 5?-triphosphates
Abramova T, et al.
Bioorganic & Medicinal Chemistry, 15, 6549-6555 (2007)
CONVERSION OF MONO- AND OLIGODEOXYRIBONUCLEOTIDES TO 5-TRIPHOSPHATES.
D E HOARD et al.
Journal of the American Chemical Society, 87, 1785-1788 (1965-04-20)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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