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重要文件

N3633

Sigma-Aldrich

β-萘黄酮

≥98%

同義詞:

5,6-苯并黄酮, BNF

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About This Item

經驗公式(希爾表示法):
C19H12O2
CAS號碼:
分子量::
272.30
Beilstein:
18991
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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化驗

≥98%

顏色

off-white to yellow

mp

164-166 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

O=C1C=C(Oc2ccc3ccccc3c12)c4ccccc4

InChI

1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H

InChI 密鑰

OUGIDAPQYNCXRA-UHFFFAOYSA-N

基因資訊

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一般說明

β-萘黄酮是一种多环芳烃。[1]

應用

β-萘黄酮已用于:
  • 作为芳烃受体激动剂,阐明其对转基因细胞色素 P450 1A1(cyp1a)报告基因的斑马鱼胚胎中 Cyp1A1 表达的影响[2]
  • 作为 AhR 激动剂,处理原代正常人表皮角质形成细胞(NHEKs),通过蛋白质印迹法研究芳香烃受体(AhR)激活[3]
  • 确定其对肌营养不良蛋白(Dp)71 表达的影响[1]
  • 刺激 Cre 重组酶的表达,并删除侧翼为 loxP 序列的等位基因[4]

生化/生理作用

β-萘黄酮是人体中芳烃受体(AhR)的外源配体。[2]它是 I 期解毒酶(CYP)和 II 期酶(UDP-GTs)和 NAD(P)H 依赖性醌氧还原酶-1(NQO1)的诱导物。它还诱导细胞色素 P450(Cyp1a)的表达。[5]BNF 通过改变转录因子的结合来抑制 Duchenne 肌营养不良基因(肌营养不良蛋白(Dp)71) 的表达。[1]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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文章

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子(如铁、铜和镉)引起的氧化损伤。

Questions

  1. How can I reconstitute the reagent β-Naphthoflavone (Ref# N3633-1G) for cell culture? Is it soluble in ethanol or DMSO?

    1 answer
    1. This product has not been tested for solubility or suitability in cell culture. The solubility is tested in Chloroform at 50 mg/ml. However, various sources report that this compound is also slightly soluble in DMSO and Ethanol. This information has not been validated. The end-user would have to determine suitability for cell culture applications.

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