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重要文件

A9584

Sigma-Aldrich

N-乙酰氧基-N-乙酰基-4-氯苯磺酰胺

≥98%

同義詞:

O-乙酰基-N-(4-氯苯基磺酰)乙酰羟肟酸

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About This Item

經驗公式(希爾表示法):
C10H10ClNO5S
CAS號碼:
分子量::
291.71
Beilstein:
5821854
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
暫時無法取得訂價和供貨情況

化驗

≥98%

形狀

flakes

儲存溫度

2-8°C

SMILES 字串

CC(=O)ON(C(C)=O)S(=O)(=O)c1ccc(Cl)cc1

InChI

1S/C10H10ClNO5S/c1-7(13)12(17-8(2)14)18(15,16)10-5-3-9(11)4-6-10/h3-6H,1-2H3

InChI 密鑰

GWYBSWWLKXEDLB-UHFFFAOYSA-N

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應用

在中性溶液中释放硝酰基 (HNO) 的化合物

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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J M Fukuto et al.
Biochemical and biophysical research communications, 187(3), 1367-1373 (1992-09-30)
N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37 degrees C. Release of nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation in rabbit thoracic aorta in
M J Lee et al.
Journal of medicinal chemistry, 35(20), 3648-3652 (1992-10-02)
In the preceding paper, analogs of chlorpropamide with an OMe substituent on the sulfonamide nitrogen were shown to inhibit aldehyde dehydrogenase (AlDH), and it was postulated that these compounds were bioactivated by O-demethylation to release nitroxyl (HN = O, nitrosyl

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