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Merck
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重要文件

935441

Sigma-Aldrich

Aldehyde functionalized hyaluronic acid

Degree of functionalization ~20%

同義詞:

HA-A, Hyaluronic acid, Hyluronic acid aldehyde, Oxidized hyaluronic acid

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About This Item

線性公式:
(C14H20NNaO11)n(C14H18NNaO11)m
分類程式碼代碼:
12352201
NACRES:
NA.28
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品質等級

形狀

powder or chunks (or fibers)

顏色

white to off-white

儲存溫度

−20°C

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一般說明

Hyaluronic acid (HA) is an important component of the natural extracellular matrix which plays a vital role in various cellular and tissue functions[1]. It represents some unique properties such as excellent gel-forming properties and chemical modification ability through hydroxyl and carboxyl groups that make them potentially useful for their application in Tissue engineering[2]. Partially oxidized hyaluronate (OHA) containing two highly aldehyde groups in the repeating unit of HA. The dialdehyde groups of OHA are capable of reductive coupling with primary amines and thus can be used in a wide range of chemical modifications of HA as hydrogel for tissue engineering applications[3][4] and regenerative medicine[5][6] drug delivery applications[7][8]

應用

HA is increasingly used for a many biomedical applications because it promotes cell migration, angiogenesis, cell viability, and proliferation. Aldehyde functionalized HA can be used to develop hydrogels for tissue engineering, regenerative medicing, bioprinting, and drug delivery applications.

特點和優勢

  • Coupling capabilities with primary amines
  • Biocompatible functionalized natural polymer
  • Promotes a variety of cellular and tissue functions

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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General Dialdehyde Click Chemistry for Amine Bioconjugation
Elahipanah S, et al.
Bioconjugate Chemistry, 28, 1422-1433 (2017)
Hyaluronic Acid and Controlled Release: A Review
Bayer S I, et al.
Molecules (Basel), 25, 2649-2649 (2020)
Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery
Sonia T, et al.
Pharmaceutics, 11, 407-407 (2019)
Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine
Franca G C, et al.
Polysaccharides, 2, 477-496 (2021)
Modified hyaluronic acid-based materials for biomedical applications
Tiwari S, et al.
International Journal of Biological Macromolecules, 121, 556-571 (2019)

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