915599

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average M_n 2,000, PCL average M_n 5,000

• 同義詞: Carboxylic acid PEG-PCL diblock copolymer, Carboxylic acid-PEG-PCL, PEG-b-PCL, PEG-PCL
• 線性公式: C₃H₅O₃[C₂H₄O]_n[C₆H₁₀O₂]_mH
• 分類程式碼代碼: 12352106
• NACRES: NA.23

屬性

• 形狀: powder or chunks
• 品質等級: 100
• 分子量: PCL average M_n 5,000 (by NMR); PCL average M_n 5,000; PEG average M_n 2,000 (by NMR); PEG average M_n 2,000
• 顏色: white to beige
• 蛋白質二硫鍵異構酶: ≤1.3 (by GPC)
• 儲存溫度: −20°C
• SMILES 字串: [H]OCCCCCC(OCCOCCC(O)=O)=O
• InChI: 1S/C11H20O6/c12-6-3-1-2-4-11(15)17-9-8-16-7-5-10(13)14/h12H,1-9H2,(H,13,14)
• InChI 密鑰: RUCUHLNLCAIHAG-UHFFFAOYSA-N

描述

應用

Carboxylic acid-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable