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Merck
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文件

900660

Sigma-Aldrich

聚(D,L-丙交酯)-b-聚(乙二醇)-b-聚(D,L-丙交酯)

5k-2k-5k

同義詞:

PLA-PEG-PLA, PLA-PEG-PLA三嵌段共聚物

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About This Item

線性公式:
HO(CH(CH3)COO)m(CH2CH2O)n(COCH(CH3)O)mH
分類程式碼代碼:
12162002

形狀

solid

儲存溫度

2-8°C

應用

由亲水性中央PEG嵌段和两个末端疏水性聚(D, L-丙交酯)(PLlA)嵌段组成的生物相容性两亲三嵌段聚合物。这些材料已被用于药物递送应用的控释制剂和纳米颗粒形成中。可通过控制每个聚合物嵌段的相对长度来制备具有各种属性的定义明确材料。羟基封端可实现对这些材料进行进一步的化学修饰。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Kun Shi et al.
Scientific reports, 6, 19077-19077 (2016-01-12)
In this study, a series of injectable thermoreversible and thermogelling PDLLA-PEG-PDLLA copolymers were developed and a systematic evaluation of the thermogelling system both in vitro and in vivo was performed. The aqueous PDLLA-PEG-PDLLA solutions above a critical gel concentration could
Mesoscale simulation and experimental studies of self-assembly behavior of a PLA-PEG-PLA triblock copolymer micelle for sustained drug delivery.
Chansuna M, et al.
Journal of Polymer Research, 21(6), 452-452 (2014)
H Danafar et al.
Pharmaceutical development and technology, 22(8), 947-957 (2016-01-08)
A conjugate of the antihypertensive drug, lisinopril, with triblock poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) copolymer was synthesized by the reaction of PLA-PEG-PLA copolymer with lisinopril in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugated copolymer was characterized in vitro by

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