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Merck
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文件

900593

Sigma-Aldrich

PAd-DalPhos

95%

同義詞:

8-[2-[Bis(2-methylphenyl)phosphino]phenyl]-1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane

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About This Item

經驗公式(希爾表示法):
C30H34O3P2
CAS號碼:
分子量::
504.54
分類程式碼代碼:
12161600
NACRES:
NA.22

品質等級

化驗

95%

形狀

powder or crystals

反應適用性

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

官能基

phosphine

應用

PAd-DalPhos is a versatile air stable pre-catalyst for C(sp2)-N coupling. It catalyzes N-arylation of amides with (hetero)aryl (pseudo)halide. It can also be used in the synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones and (hetero)aryl bromides.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Nickel?Catalyzed N?Arylation of Primary Amides and Lactams with Activated (Hetero) aryl Electrophiles.
Lavoie C M, et al.
Chemistry?A European Journal , 22(52), 18752-18755 (2016)
Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1, 3-di (hetero) aryl-1H-indazoles from hydrazine, o-chloro (hetero) benzophenones, and (hetero) aryl bromides.
Wiethan C, et al.
Organic & Biomolecular Chemistry, 15(23), 5062-5069 (2017)
Christopher M Lavoie et al.
Nature communications, 7, 11073-11073 (2016-03-24)
Palladium-catalysed C(sp(2))-N cross-coupling (that is, Buchwald-Hartwig amination) is employed widely in synthetic chemistry, including in the pharmaceutical industry, for the synthesis of (hetero)aniline derivatives. However, the cost and relative scarcity of palladium provides motivation for the development of alternative, more

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