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重要文件

860646

Sigma-Aldrich

1-甲基-DL-色氨酸

97%

同義詞:

1-甲基-DL-色氨酸, 1-甲基色氨酸, 2-氨基-3-(1-甲基-1H-吲哚-3-基)丙酸, 2-氨基-3-(1-甲基吲哚-3-基)丙酸, DL-1-甲基色氨酸, N′-甲基-DL-色氨酸

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About This Item

經驗公式(希爾表示法):
C12H14N2O2
CAS號碼:
分子量::
218.25
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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品質等級

化驗

97%

形狀

solid

mp

250 °C (dec.) (lit.)

官能基

amine
carboxylic acid

SMILES 字串

Cn1cc(CC(N)C(O)=O)c2ccccc12

InChI

1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)

InChI 密鑰

ZADWXFSZEAPBJS-UHFFFAOYSA-N

應用

1-甲基- DL -色氨酸是吲哚胺 2,3 双加氧酶-1 (IDO1) 的竞争性抑制剂,已用于研究炎症诱导的小鼠抑郁症[1]和合胞病毒诱导的毛细支气管炎。[2]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Neda Milosavljevic et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 23(8), 1040-1050 (2017-05-10)
Mesenchymal stem cells (MSCs) are, due to immunomodulatory characteristics, considered as novel agents in the treatment of immune-mediated acute liver failure. Although it is known that MSCs can regulate activation of T lymphocytes, their capacity to modulate function of neutrophils
Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2, 3 dioxygenase.
Vichaya, Elisabeth G et al.
Neuropsychopharmacology (2018)
Martin Böttcher et al.
Stem cells (Dayton, Ohio), 34(2), 516-521 (2015-10-21)
Mesenchymal stromal cells (MSCs) possess numerous regenerative and immune modulating functions. Transplantation across histocompatibility barriers is feasible due to their hypo-immunogenicity. MSCs have emerged as promising tools for treating graft-versus-host disease following allogeneic stem cell transplantation. It is well established
Qi-Xiang Ye et al.
Experimental and therapeutic medicine, 14(3), 1884-1891 (2017-10-01)
Cytotoxic T-lymphocyte-associated protein 4 immunoglobulin (CTLA4Ig) and anti-cluster of differentiation 154 (anti-CD154) are able to block B7/CD28 and CD40/CD154 co-stimulatory signals in T cells. Additionally, they promote hematopoietic stem cell transplantation (HSCT) in sensitized recipients and are able to induce
Seung-Ha Yang et al.
Experimental & molecular medicine, 41(5), 315-324 (2009-03-25)
Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying mechanisms are not clear. In this study, we investigated the mechanisms of the immunoregulatory activity of MSCs on T cells. Irradiated MSCs co-cultured with either na?ve or pre-activated

Questions

  1. What is the recommended storage temperature and solubility of this product no.860646, 1-Methyl-DL-tryptophan?

    1 answer
    1. This product may be stored at room temperature. The solubility of this product has not been determined. However, according to the literature, this compound is soluble in methanol and acetic acid (2 %) at approximately 0.1 mg/mL and 1 mg/mL, respectively.

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