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858781

Sigma-Aldrich

3,4-二羟基苄胺 氢溴酸盐

98%

同義詞:

4-(氨甲基)儿茶酚 氢溴酸盐, DHBA 氢溴酸盐

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About This Item

線性公式:
(HO)2C6H3CH2NH2 · HBr
CAS號碼:
分子量::
220.06
Beilstein:
4002646
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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品質等級

化驗

98%

形狀

crystals

mp

184-186 °C (lit.)

官能基

amine

SMILES 字串

Br.NCc1ccc(O)c(O)c1

InChI

1S/C7H9NO2.BrH/c8-4-5-1-2-6(9)7(10)3-5;/h1-3,9-10H,4,8H2;1H

InChI 密鑰

BVFZTXFCZAXSHN-UHFFFAOYSA-N

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應用

<ul>
<li><strong>3,4-二羟基苯乙胺的氧化聚合:</strong>用3,4-二羟基苯乙胺通过氧化聚合制备聚3,4-二羟基苯乙胺(PDHBA),说明本品作为多巴胺的偏小类似物(lower homolog)可用于合成与材料科学(Petran et al., 2023)。</li>
<li><strong>尿游离甲氧基肾上腺素类物质的检测:</strong>以3,4-二羟基苯乙胺为内标,提高尿游离甲氧基肾上腺素类物质检测的准确性,用于嗜铬细胞瘤和副神经节瘤诊断。表明临床诊断应用意义(Wang et al., 2020)。</li>
<li><strong>HPLC-ECD方法开发:</strong>以3,4-二羟基苯乙胺为内标,开发HPLC-ECD方法分析血浆中的维生素C。体现其化学性质有利于生化研究的分析方法改进(Clark and Frank, 2016)。</li>
<li><strong>儿茶酚胺类物质的荧光分析:</strong>用3,4-二羟基苯乙胺作为内标测定大鼠脑组织中的儿茶酚胺及相关物质,体现神经化学分析和研究应用价值(Fonseca et al., 2017)。</li>
</ul>

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Ki Sung Kang et al.
PloS one, 5(8), e11951-e11951 (2010-08-12)
A combination of levodopa (L-DOPA) and carbidopa is the most commonly-used treatment for symptom management in Parkinson's disease. Studies have shown that concomitant use of a COMT inhibitor is highly beneficial in controlling the wearing-off phenomenon by improving L-DOPA bioavailability
E C Chan et al.
Rapid communications in mass spectrometry : RCM, 14(21), 1959-1964 (2000-11-21)
An assay of norepinephrine (NE), epinephrine (E), dopamine (DA), normetanephrine (NE) and metanephrine (MN) based on high-performance liquid chromatography (HPLC) in combination with atmospheric pressure chemical ionization mass spectrometry (APcI-MS) is described. The catecholamines and metanephrines were extracted from urine
F Boomsma et al.
Journal of cardiovascular pharmacology, 22(2), 198-202 (1993-08-01)
We noted rapid breakdown at 4 degrees and 20 degrees C of dopamine (DA) (but not of (nor)epinephrine and epinine) in pig plasma, but not in human plasma. The enzyme responsible appears to be a semicarbazide-sensitive amine oxidase (SSAO) because
J A Prezioso et al.
Pigment cell research, 3(2), 49-54 (1990-03-01)
The rationale for melanoma specific dihydroxybenzene containing antitumor agents is based in part upon the ability of the enzyme tyrosinase to oxidize these pro drugs to toxic intermediates. In situ tyrosinase activity was demonstrated to be affected by both cell
F Boomsma et al.
Journal of chromatography, 621(1), 82-88 (1993-11-17)
We report a rapid breakdown of dopamine and especially of 3,4-dihydroxybenzylamine, the frequently-used internal standard in catecholamine determinations, in plasma of many but not all animal species. Species investigated were cow, sheep, goat, pig, horse, rabbit, dog, guinea pig, mouse

Questions

  1. Can it be stored at -20C

    1 answer
    1. This product is stored at room temperature. In general, powder materials are not effected by freezer storage, however this item has not been tested under these storage conditions.

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