推薦產品
化驗
95%
光學活性
[α]24/D −443°, c = 1.7 in H2O
雜質
10% ethyl acetate and chloroform
mp
150-160 °C (dec.) (lit.)
SMILES 字串
COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
InChI
1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChI 密鑰
IAKHMKGGTNLKSZ-INIZCTEOSA-N
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應用
有关该生物碱在新陈代谢和药代动力学方面的综述，请查看 Z. Gastroenterol.。
取代透過
產品號碼
描述
訂價
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral - Muta. 1B
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Chem. Abstr., 118, 32389e-32389e (1993)
A Sabouraud et al.
Zeitschrift fur Gastroenterologie, 30 Suppl 1, 35-39 (1992-03-01)
Thanks to the development of a sensitive and specific radioimmunoassay for colchicine, the pharmacokinetics of colchicine is now well-established after single oral doses. Absorption is characterized by a zero-order rate constant while disposition appears biexponential with a rapid distribution phase
Sébastien Fortin et al.
Journal of medicinal chemistry, 54(13), 4559-4580 (2011-05-25)
Sixty-one phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB-SOs) and 13 of their tetrahydro-2-oxopyrimidin-1(2H)-yl analogues (PPB-SOs) were prepared and biologically evaluated. The antiproliferative activities of PIB-SOs on 16 cancer cell lines are in the nanomolar range and unaffected in cancer cells resistant to colchicine, paclitaxel
Samir Messaoudi et al.
Journal of medicinal chemistry, 52(14), 4538-4542 (2009-06-18)
Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize without need to control the
Ravi Kumar Anchoori et al.
Journal of medicinal chemistry, 51(19), 5953-5957 (2008-09-10)
Current microtubule inhibitory agents used in the clinic to treat cancer have severe side effects, and development of resistance is frequent. We have evaluated the antitumor effect of a novel 30-compound library of phenoxy pyridine and phenyl sulfanyl pyridine derivatives.
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