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809292

Sigma-Aldrich

3-Methyl-3-(perfluoropyridin-4-yl)-1,5-dioxaspiro[5.5]undecane-2,4-dione

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About This Item

經驗公式（希爾表示法）:
C15H13F4NO4
CAS號碼:
1632145-37-9
分子量：:
347.26
MDL號碼:
MFCD28359682
分類程式碼代碼:
12352200
PubChem物質ID:
329769153
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形狀

powder or crystals

儲存溫度

2-8°C

SMILES 字串

O=C(C1(C)C2=C(F)C(F)=NC(F)=C2F)OC3(CCCCC3)OC1=O

InChI

1S/C15H13F4NO4/c1-14(7-8(16)10(18)20-11(19)9(7)17)12(21)23-15(24-13(14)22)5-3-2-4-6-15/h2-6H2,1H3

InChI 密鑰

PWILGKQKDOVPSH-UHFFFAOYSA-N

一般說明

3-Methyl-3-(perfluoropyridin-4-yl)-1,5-dioxaspiro[5.5]undecane-2,4-dione is a substituted Meldrum′s acid derivative. It can be prepared by reacting 3-methyl-1,5-dioxaspiro[5.5]undecane-2,4-dione with pentafluoropyridine.[1]

應用

This compound undergoes cycloreversion to form the fluoro(hetero)aryl ketene, which undergoes efficient coupling with nucleophiles and allows rapid incorporation of highly fluorinated α-fluoro(hetero)aryl acetic acid derivatives.

其他說明

Selective Perfluoro- and Polyfluoroarylation of Meldrum′s Acid

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

防範說明

P305 + P351 + P338

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number

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Sameera M Senaweera et al.
The Journal of organic chemistry, 79(21), 10466-10476 (2014-10-02)
This work describes the facile and mono-selective per- and polyfluoroarylation of Meldrum's acid to generate a versatile synthon for highly fluorinated α-phenyl acetic acid derivatives, which provide straightforward access to fluorinated building blocks. The reaction takes place quickly, and most

相關內容

Weaver Group – Professor Product Portal

Organofluorine chemistry is an essential part of drug discovery programs as well as agrochemical programs and even plays a major role in materials chemistry. Despite the undeniable importance of fluorinated organic molecules, our ability to synthesize these substrates is lacking - though arguably it is better than that of Nature. Consequently, methods that allow facile access to fluorinated molecules are important especially when they provide unique access to fluorinated chemical space.

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