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Merck
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文件

804401

Sigma-Aldrich

PyFluor

同義詞:

2-吡啶磺酰氟

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About This Item

經驗公式(希爾表示法):
C5H4FNO2S
CAS號碼:
分子量::
161.15
MDL號碼:
分類程式碼代碼:
12352101
PubChem物質ID:
NACRES:
NA.22

化驗

95% (HPLC)

品質等級

形狀

solid

mp

29-34 °C

儲存溫度

2-8°C

SMILES 字串

O=S(C1=CC=CC=N1)(F)=O

InChI

1S/C5H4FNO2S/c6-10(8,9)5-3-1-2-4-7-5/h1-4H

InChI 密鑰

FCFXLXGZHDHJLB-UHFFFAOYSA-N

應用

2-吡啶磺酰氟可与脒或胍基碱一起用于伯醇和仲醇的脱氧氟化反应。与其他常见的脱氧氟化试剂相比,如DAST,在某些底物上直接比较时具有较少的消除副产物。

象形圖

Corrosion

訊號詞

Danger

危險聲明

危險分類

Eye Dam. 1 - Skin Corr. 1B

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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文章

The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules.

相關內容

Research in the Doyle group focuses on two areas: nucleophilic fluorination and nickel catalysis. The Doyle group has developed several reagents that advance these research areas. In fluorination, 2-pyridinesulfonyl fluoride (PyFluor) can be used for the mild deoxyfluorination of primary and secondary alcohols, a procedure which is normally accomplished by the sensitive reagent DAST. In nickel catalysis, the Doyle group has developed a modular, air-stable nickel precatalyst, [(TMEDA)Ni(o-tolyl)Cl], which has broad utility for a wide variety of reactions. This precatalyst can be used in place of Ni(cod)2, NiCl2, as well as other reported precatalysts. Doyle has also reported electron-deficient olefin ligands as a new class of ligand for accelerated reductive elimination. In particular, the sultam-derived ligand Fro-DO has been found to be critical for high yields in the cross-coupling of tertiary aziridines to form quaternary centers.

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