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Merck
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重要文件

804223

Sigma-Aldrich

3-oxo-C12-aniline

同義詞:

3-oxo-N-phenyl-Dodecanamide, LasR inhibitor, non-hydrolysable head group

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About This Item

經驗公式(希爾表示法):
C18H27NO2
CAS號碼:
分子量::
289.41
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.22
暫時無法取得訂價和供貨情況

形狀

solid

儲存溫度

−20°C

SMILES 字串

CCCCCCCCCC(CC(NC1=CC=CC=C1)=O)=O

InChI

1S/C18H27NO2/c1-2-3-4-5-6-7-11-14-17(20)15-18(21)19-16-12-9-8-10-13-16/h8-10,12-13H,2-7,11,14-15H2,1H3,(H,19,21)

InChI 密鑰

GYOZLHQAMICVMN-UHFFFAOYSA-N

應用

This analog mimics the native 3-oxo-C12 AHL signal utilized by Pseudomonas aeruginosa for quorum sensing, yet contains a non-hydrolysable aniline head group. 3-oxo-C12-aniline is a strong inhibitor of the LasR receptor in P. aeruginosa.[1][2]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands.
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Design, synthesis and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing
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Journal of the American Chemical Society, 129(44), 13613-13625 (2007-10-12)
Bacteria use a language of low molecular weight ligands to assess their population densities in a process called quorum sensing. This chemical signaling process plays a pivotal role both in the pathogenesis of infectious disease and in beneficial symbioses. There

相關內容

We study quorum sensing, how bacteria sense their density. Synthesized compounds modulate pathways, aiding research on infections in various hosts.

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