792373

2-氯-2,2-二氟苯乙酮

95%

• 同義詞: 2-Chloro-2,2-difluoro-1-phenylethanone, Chlorodifluoromethyl phenyl ketone, α-Chloro-α,α-difluoroacetophenone
• 線性公式: C₆H₅COCF₂Cl
• CAS號碼: 384-67-8
• 分子量：: 190.57
• Beilstein: 2251448
• MDL號碼: MFCD00042123
• 分類程式碼代碼: 12352101
• PubChem物質ID: 329768330
• NACRES: NA.22

屬性

• 化驗: 95%
• 形狀: liquid
• 反應適用性: reaction type: C-C Bond Formation
• 折射率: n20/D 1.4954; n20/D 1.497 (lit.)
• bp: 94-96 °C/35 mmHg (lit.)
• 密度: 1.293 g/mL at 25 °C (lit.); 1.3178 g/mL at 25 °C
• 官能基: chloro; fluoro; ketone; phenyl
• SMILES 字串: FC(F)(Cl)C(=O)c1ccccc1
• InChI: 1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
• InChI 密鑰: MNOONJNILVDLSW-UHFFFAOYSA-N

描述

一般說明

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem -difluoromethene derived compounds.[1]

應用

2-Chloro-2,2-difluoroacetophenone can be used:

• As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.[2]
• As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.[3]
• As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.[4]

Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 160.0 °F
• 閃點（°C）: 71.1 °C