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Merck
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文件

777323

Sigma-Aldrich

Cy5-叠氮化物

95% (HPLC)

同義詞:

Cy5 Azide Fluorescent Probe

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About This Item

經驗公式（希爾表示法）:
C49H78N8O10S3
分子量：:
1035.39
分類程式碼代碼:
12352125
PubChem物質ID:
329767899
NACRES:
NA.22

品質等級

100

化驗

95% (HPLC)

形狀

solid

反應適用性

reaction type: click chemistry

ε (extinction coefficient)

251,000

螢光

λex 647 nm; λem 663 nm

儲存溫度

−20°C

SMILES 字串

CC1(C)C(/C=C/C=C/C=C(N2CCCS([O-])(=O)=O)\C(C)(C)C3=C2C=CC(S([O-])(=O)=O)=C3)=[N+](CCCCCC(NCCCN=[N+]=[N-])=O)C4=C1C=C(S([O-])(=O)=O)C=C4.CC[NH+](CC)CC.CC[NH+](CC)CC

InChI

1S/C37H48N6O10S3.2C6H15N/c1-36(2)29-25-27(55(48,49)50)16-18-31(29)42(22-10-6-9-15-35(44)39-20-11-21-40-41-38)33(36)13-7-5-8-14-34-37(3,4)30-26-28(56(51,52)53)17-19-32(30)43(34)23-12-24-54(45,46)47;2*1-4-7(5-2)6-3/h5,7-8,13-14,16-19,25-26H,6,9-12,15,20-24H2,1-4H3,(H3-,39,44,45,46,47,48,49,50,51,52,53);2*4-6H2,1-3H3

InChI 密鑰

NJSWGOLBDDXJQO-UHFFFAOYSA-N

相關類別

應用

叠氮化物修饰的花青染料可用于在叠氮-炔环加成后通过荧光光谱检测或标记含炔烃或环辛炔的分子或生物分子。

溶解度： DMSO、DMF、MeOH

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Shanqiao Wei et al.
PloS one, 12(9), e0185010-e0185010 (2017-09-20)
Most B cell cancers overexpress the enzyme activation-induced deaminase at high levels and this enzyme converts cytosines in DNA to uracil. The constitutive expression of this enzyme in these cells greatly increases the uracil content of their genomes. We show
Tom van der Wel et al.
Nature communications, 11(1), 3216-3216 (2020-06-27)
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases. By substituting a serine
Markus Muttenthaler et al.
Australian journal of chemistry, 73(4), 327-333 (2020-05-13)
In-solution conjugation is the most commonly used strategy to label peptides and proteins with fluorophores. However, lack of site-specific control and high costs of fluorophores are recognised limitations of this approach. Here, we established facile access to grams of Cy5-COOH
Valentina M Farzan et al.
Bioconjugate chemistry, 28(10), 2599-2607 (2017-09-19)
We developed a novel technique for the efficient conjugation of oligonucleotides with various alkyl azides such as fluorescent dyes, biotin, cholesterol, N-acetylgalactosamine (GalNAc), etc. using copper-catalysed alkyne-azide cycloaddition on the solid phase and CuI·P(OEt)
Björn Trebels et al.
Scientific reports, 10(1), 1090-1090 (2020-01-25)
Several studies showed adult persisting neurogenesis in insects, including the red flour beetle Tribolium castaneum, while it is absent in honeybees, carpenter ants, and vinegar flies. In our study, we focus on cell proliferation in the adult mushroom bodies of
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文章

Click Chemistry in Drug Discovery

Drug discovery process by utilizing chemistry reaction of Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes with organoazides to yield 1,4-disubstituted 1,2,3-triazoles.

藥物發現中的點擊化學

利用 Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes 與 organoazides 的化學反應生成 1,4-disubstituted 1,2,3-triazoles 的藥物發現過程。

螢光生命週期測量

螢光生命週期測量比基於強度的測量更具優勢。其應用包括螢光生命週期檢測、感測和 FLI。

Fluorescence Lifetime Measurement

Fluorescence lifetime measurement is advantageous over intensity-based measurements. Applications include fluorescence lifetime assays, sensing and FLI.

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

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