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761052

Sigma-Aldrich

1H-Imidazole-1-carboxylic acid-3-butenyl ester

97%

同義詞:

Heller-Sarpong Reagent-Homoallyl

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About This Item

經驗公式(希爾表示法):
C8H10N2O2
CAS號碼:
分子量::
166.18
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22

化驗

97%

形狀

liquid

折射率

n20/D 1.488

密度

1.107 g/mL at 25 °C

儲存溫度

2-8°C

SMILES 字串

O=C(OCCC=C)N1C=CN=C1

InChI

1S/C8H10N2O2/c1-2-3-6-12-8(11)10-5-4-9-7-10/h2,4-5,7H,1,3,6H2

InChI 密鑰

BNGLJMQCDKTXTL-UHFFFAOYSA-N

應用

1H-Imidazole-1-carboxylic acid-3-butenyl ester can be used:
  • To prepare bis-naphthyridine derived cyclic mismatch binding ligands (CMBLs) which exhibit DNA repeat binding properties.
  • As a reagent in the chemoselective esterification of carboxylic acids.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

230.0 °F

閃點(°C)

110 °C


分析證明 (COA)

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Design and synthesis of cyclic Mismatch-Binding Ligands (CMBLs) with variable linkers by Ring-Closing metathesis and their photophysical and DNA repeat binding properties
Mukherjee S, et al.
Chemistry?A European Journal , 23, 11385-11396 (2017)
Chemoselective esterification and amidation of carboxylic acids with imidazole carbamates and ureas
Heller ST and Sarpong R
Organic Letters, 12(20), 4572-4575 (2010)

相關內容

Professor Heller and coworkers are engaged in the development of mild and chemoselective acylation reactions using carbonylazole-derived reagents. To that end, they have developed a suite of carbonylimidazole derivatives for facile and chemoselective esterification (MImC, etc.) and amidation (WImC) of carboxylic acids, in collaboration with Professor Richmond Sarpong.

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