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Merck
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重要文件

760943

Sigma-Aldrich

Poly(ethylene glycol), 8 acetylene dendron, generation 2

average Mn 21,000

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About This Item

分類程式碼代碼:
12162002
NACRES:
NA.23
暫時無法取得訂價和供貨情況

描述

acetylene surface groups

形狀

solid

分子量

PEG average Mn 20,000 (n~450; esterified with 8 acetylene groups)
Mn 16,000-21,000 (by NMR)
average Mn 21,000

特點

generation 2

號表面基團

8

轉變溫度

Tm 56-60 °C

Mw/Mn

≤1.4

官能基

alkyne

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一般說明

Dendrimers and dendrons are symmetrically branched polymer structures that possess a well-defined spatial distribution of functional groups.[1] Dendrimers are chemically modified by attaching poly ethylene glycol (PEG) molecule to increase its solubility and prolong circulation half-life.[2] “Clickable groups”, such as primary acetylenes, are introduced to the mono dispersed dendritic structures, using “click” chemistry.[1][3]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Applications of Orthogonal, ?click? Chemistries in the synthesis of functional soft materials
Chemical Reviews, 109 (11), 5620-5686 null
Degradable Poly (ethylene glycol) hydrogels for 2 D and 3D cell culture
Andrea M Kasko
Material Matters, 6 (3), 67-75 null
Biocompatible Dendritic Building Blocks for Advanced Biomedical Reasearch
Michael Malkoch and Andreas M Nystrom
Material Matters, 7(3), 47-49 null
Huiyuan Li et al.
Molecules (Basel, Switzerland), 18(8), 9797-9817 (2013-08-21)
Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly used to construct diverse chemotypes

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