推薦產品
描述
C9H7NO · ½H2SO4 (Linear Formula)
化驗
≥98.0% (dry substance, T)
雜質
~5% water
顏色
yellow
抗生素活性譜
fungi
作用方式
DNA synthesis | interferes
enzyme | inhibits
SMILES 字串
OS(O)(=O)=O.Oc1cccc2cccnc12.Oc3cccc4cccnc34
InChI
1S/2C9H7NO.H2O4S/c2*11-8-5-1-3-7-4-2-6-10-9(7)8;1-5(2,3)4/h2*1-6,11H;(H2,1,2,3,4)
InChI 密鑰
YYVFXSYQSOZCOQ-UHFFFAOYSA-N
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一般說明
化学结构：喹诺酮类
應用
8-羟基喹啉半硫酸盐 (8-OHQ) 可用于制备具有蛋白酶抑制活性的 Cu [8-OHQ] 2。[1]
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Kenyon G Daniel et al.
Biochemical pharmacology, 67(6), 1139-1151 (2004-03-10)
Here we report that organic copper complexes can potently and selectively inhibit the chymotrypsin-like activity of the proteasome in vitro and in vivo. Several copper compounds, such as NCI-109268 and bis-8-hydroxyquinoline copper(II) [Cu(8-OHQ)(2)], can inhibit the chymotrypsin-like activity of purified
Saverio Tardito et al.
Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)
This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and
Erik H J G Aarntzen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06)
Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy
M Škodová et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 13(18), 4244-4250 (2012-11-08)
Improvements in cancer diagnostics and therapy have recently attracted the interest of many different branches of science. This study presents one of the new possible approaches in the diagnostics and therapy of cancer by using polymeric chelates as carriers. Graft
Donald J Messner et al.
Digestive diseases and sciences, 58(7), 1899-1908 (2013-04-06)
Iron overload is associated with increased severity of nonalcoholic fatty liver disease (NAFLD) including progression to nonalcoholic steatohepatitis and hepatocellular carcinoma. To identify potential role(s) of iron in NAFLD, we measured its effects on pathways of oxidative stress and insulin
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