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重要文件

375063

Sigma-Aldrich

异氰酸1-金刚烷酯

97%

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About This Item

經驗公式(希爾表示法):
C11H15NO
CAS號碼:
分子量::
177.24
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
暫時無法取得訂價和供貨情況

化驗

97%

mp

144-146 °C (lit.)

官能基

isocyanate

SMILES 字串

O=C=NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2

InChI

1S/C11H15NO/c13-7-12-11-4-8-1-9(5-11)3-10(2-8)6-11/h8-10H,1-6H2/t8-,9+,10-,11-

InChI 密鑰

VBHCPGFCIQDXGZ-BIBSGERRSA-N

一般說明

异氰酸-1-金刚烷酯是一种异氰酸酯衍生物。

應用

1-金刚烷基异氰酸酯可用于制备:
  • 金刚烷基功能化纳米颗粒,通过巯基修饰纳米颗粒的硫醇-异氰酸酯反应 1 4-[3-(芳基或-环烷基)脲基] 丁酰基化合物[1]
  • DMF 中与 4-氨基丁酸反应的 4-(3-金刚烷-1-基-脲基)丁酸[2]
  • 丁酰氧基化合物[2]
  • 12-(3-金刚烷-1-基-脲基)十二酸 (AUDA)[3]
  • 金刚烷胺苯磺酰胺脲[4]
  • 与羟基烷基胺反应的 1-金刚烷-1-基-3-(羟烷基)脲[5]

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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In-Hae Kim et al.
Journal of medicinal chemistry, 47(8), 2110-2122 (2004-04-02)
The soluble epoxide hydrolase (sEH) is involved in the metabolism of endogenous chemical mediators that play an important role in blood pressure regulation and inflammation. 1,3-Disubstituted ureas are potent inhibitors of sEH that are active both in vitro and in
E Jeffrey North et al.
Bioorganic & medicinal chemistry, 21(9), 2587-2599 (2013-03-19)
Out of the prominent global ailments, tuberculosis (TB) is still one of the leading causes of death worldwide due to infectious disease. Development of new drugs that shorten the current tuberculosis treatment time and have activity against drug resistant strains
In-Hae Kim et al.
Journal of medicinal chemistry, 50(21), 5217-5226 (2007-09-27)
Soluble epoxide hydrolase (sEH) is a therapeutic target for treating hypertension and inflammation. 1,3-Disubstituted ureas functionalized with an ether group are potent sEH inhibitors. However, their relatively low metabolic stability leads to poor pharmacokinetic properties. To improve their bioavailability, we
In-Hae Kim et al.
Bioorganic & medicinal chemistry, 15(1), 312-323 (2006-10-19)
The soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in blood pressure regulation and vascular inflammation. 12-(3-Adamantan-1-yl-ureido)-dodecanoic acid (AUDA, 1) is a very active inhibitor of sEH both in vitro and in
Kathrin Isenbügel et al.
Macromolecular rapid communications, 31(24), 2121-2126 (2011-05-14)
Stable nanoparticle vesicles were for the first time prepared from adamantyl- and cyclodextrin (CD)-modified silica nanoparticles forming host-guest interactions in aqueous solution. Adamantyl-functionalized nanoparticles were obtained from thiol-isocyanate reaction of thiol-modified nanoparticles with 1-adamantyl isocyanate. The CD modified silica particles

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