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Merck
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重要文件

345717

Sigma-Aldrich

1-溴-2,3-二氟苯

98%

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About This Item

線性公式:
BrC6H3F2
CAS號碼:
分子量::
192.99
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
暫時無法取得訂價和供貨情況

化驗

98%

形狀

liquid

折射率

n20/D 1.509 (lit.)

密度

1.724 g/mL at 25 °C (lit.)

SMILES 字串

Fc1cccc(Br)c1F

InChI

1S/C6H3BrF2/c7-4-2-1-3-5(8)6(4)9/h1-3H

InChI 密鑰

RKWWASUTWAFKHA-UHFFFAOYSA-N

一般說明

Microbial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.[1]

應用

1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372).[2] It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.[3]

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

141.8 °F - closed cup

閃點(°C)

61 °C - closed cup

個人防護裝備

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


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New metabolites from the microbial oxidation of fluorinated aromatic compounds.
Hudlicky T, et al.
Journal of Fluorine Chemistry, 89(1), 23-30 (1998)
Reaction of chloropentafluorobenzene and 2, 3-and 2, 6-difluorobromobenzenes with lithium dimethylphosphide.
Goryunov LI, et al.
Russ. J. Org. Chem., 45(12), 1859-1861 (2009)
Guanglin Luo et al.
ACS medicinal chemistry letters, 3(4), 337-341 (2012-04-12)
Calcitonin gene-related peptide (CGRP) receptor antagonists have been clinically shown to be effective in the treatment of migraine, but identification of potent and orally bioavailable compounds has been challenging. Herein, we describe the conceptualization, synthesis, and preclinical characterization of a

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