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About This Item
線性公式:
(CH3)4C3HCO2H
CAS號碼:
分子量：:
142.20
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
暫時無法取得訂價和供貨情況
推薦產品
化驗
99%
mp
120-121 °C (lit.)
官能基
carboxylic acid
SMILES 字串
CC1(C)C(C(O)=O)C1(C)C
InChI
1S/C8H14O2/c1-7(2)5(6(9)10)8(7,3)4/h5H,1-4H3,(H,9,10)
InChI 密鑰
SFHVXKNMCGSLAR-UHFFFAOYSA-N
一般說明
應用
2,2,3,3-Tetramethylcyclopropanecarboxylic acid was used as a starting material for the synthesis of central nervous system-active compounds.[1]
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Sara Eyal et al.
Biochemical pharmacology, 69(10), 1501-1508 (2005-04-29)
The tumor cells toxicity of the antiepileptic drug valproic acid (VPA) has been associated with the inhibition of histone deacetylases (HDACs). We have assessed, in comparison to VPA, the HDACs inhibition and tumor cells cytotoxicities of CNS-active VPA's constitutional isomers
Preparation of tetramethylcyclopropanecarboxylic-14C acid and insecticidal terallethrin-14C from it.
A Yoshitake et al.
Radioisotopes, 30(8), 452-454 (1981-08-01)
Neta Pessah et al.
Journal of medicinal chemistry, 52(8), 2233-2242 (2009-03-20)
2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA, 4) is a cyclic analogue of the antiepileptic drug (AED) valproic acid (VPA) (1). alpha-F, alpha-Cl, alpha-Br, and alpha-methyl derivatives of 4 and their amides were synthesized and tested in rodent models for anticonvulsant potency and AED-induced
Tawfeeq Shekh-Ahmad et al.
Epilepsy research, 98(2-3), 238-246 (2011-11-08)
Valproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs. 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA) is an inactive cyclopropyl analogue of VPA that serves as a starting material for the synthesis of CNS-active compounds. New conjugation
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