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Merck
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文件

257443

Sigma-Aldrich

氟乙腈

98%

同義詞:

2-Fluoroacetonitrile, Fluoromethyl cyanide, Monofluoroacetonitrile

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About This Item

線性公式:
FCH2CN
CAS號碼:
分子量::
59.04
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

98%

形狀

liquid

折射率

n20/D 1.333 (lit.)

bp

79-80 °C (lit.)

密度

1.061 g/mL at 25 °C (lit.)

SMILES 字串

FCC#N

InChI

1S/C2H2FN/c3-1-2-4/h1H2

InChI 密鑰

GNFVFPBRMLIKIM-UHFFFAOYSA-N

應用

Fluoroacetonitrile has been used in preparation of:
  • 2-fluoromethyl-4,4,6-trimethyl-1,3-oxazine
  • α-fluorinated acetophenone
  • 2-amino-2-fluoromethyl-3-pentenenitrile, a key intermediate in the synthesis of 2,5-diamino-2-fluoromethyl-3(E)-pentenoic acid

象形圖

FlameSkull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

6.8 °F - closed cup

閃點(°C)

-14 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


分析證明 (COA)

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2-Fluoromethyl-4, 4, 6-trimetiiyl-1, 3-oxasine as a new reagent for the preparation of a-fluoroaldehydes.
Patrick TB, et al.
Tetrahedron Letters, 31(2), 179-182 (1990)
Preparative flow techniques. 2. Grignard addition reaction on fluoroaceto-nitrile: Synthesis of 2-amino-2-fluoromethyl-3-pentenenitrile.
Gerhart F, et al.
Journal of Fluorine Chemistry, 50(2), 243-249 (1990)
Erum Raja et al.
Tetrahedron letters, 52(40), 5170-5172 (2012-03-03)
Fluoro-substituted aliphatic nitriles are shown to undergo the Houben-Hoesch reactions with arenes in CF(3)SO(3)H to give fluoro-substituted ketones in good yields. The fluorine substituents appear to enhance the reactivities of the nitriles (and the nitrilium ion intermediates) compared to similar
Santanu Mondal et al.
ACS chemical biology, 13(4), 1057-1065 (2018-03-09)
Protein arginine deiminases (PADs) play an important role in the pathogenesis of various diseases, including rheumatoid arthritis, multiple sclerosis, lupus, ulcerative colitis, and breast cancer. Therefore, the development of PAD inhibitors has drawn significant research interest in recent years. Herein

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