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Merck
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重要文件

252999

Sigma-Aldrich

尼亚酰铵

95%

同義詞:

N-异烟酰-N′-[β-(N-苄基甲酰氨基)乙基]肼, N-苄基-β-(异烟肼)丙酰胺, 吡啶-4-甲酰 2-[2-(苄基氨基甲酰)乙基]酰肼

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About This Item

經驗公式(希爾表示法):
C16H18N4O2
CAS號碼:
分子量::
298.34
Beilstein:
492941
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
暫時無法取得訂價和供貨情況

化驗

95%

mp

152-154 °C (lit.)

溶解度

methanol: soluble 10 mg/mL, clear, colorless to faintly yellow

官能基

amide
amine
hydrazide
phenyl

SMILES 字串

O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2

InChI

1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)

InChI 密鑰

NOIIUHRQUVNIDD-UHFFFAOYSA-N

基因資訊

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一般說明

Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied[1]. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated[2].

生化/生理作用

非选择性 MAO-A/B 抑制剂。

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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F Datiche et al.
Brain research, 671(1), 27-37 (1995-02-06)
Retrograde axonal transport of the cholera toxin B subunit (CTb) was combined with 5-HT immunohistochemistry to determine the origin of the serotonergic innervation of the piriform cortex (PC) in the rat. After iontophoretic CTb injections in the PC, a substantial
Subsensitivity of the beta-adrenergic receptor-linked adenylate cyclase system of rat pineal gland following repeated treatment with desmethylimipramine and nialamide.
J A Moyer et al.
Molecular pharmacology, 19(2), 187-193 (1981-03-01)
C F Meehan et al.
The Journal of physiology, 590(2), 289-300 (2011-11-23)
Recently, transgenic mice have been created with mutations affecting the components of the mammalian spinal central pattern generator (CPG) for locomotion; however, it has currently only been possible to evoke fictive locomotion in mice, using neonatal in vitro preparations. Here, we demonstrate
Jason A Nieuwsma et al.
Annals of internal medicine, 167(10), 725-735 (2017-11-14)
Patients who have had an acute coronary syndrome (ACS) event have an increased risk for depression. To evaluate the diagnostic accuracy of depression screening instruments and to compare safety and effectiveness of depression treatments in adults within 3 months of
T Karhula et al.
Neuroscience letters, 194(1-2), 85-88 (1995-07-14)
Localization of 5-hydroxytryptamine immunoreactivity was studied in the rat coeliac-superior mesenteric ganglion complex and in the porcine superior and inferior mesenteric ganglia by the indirect immunofluorescence technique. In normal rats, only 5-hydroxytryptamine immunoreactive SIF cells were seen in the coeliac-superior

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