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Merck
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重要文件

232947

Sigma-Aldrich

2-(三氟甲基)苯甲腈

98%

同義詞:

α,α,α-三氟邻甲基苯甲腈

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About This Item

線性公式:
CF3C6H4CN
CAS號碼:
分子量::
171.12
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
暫時無法取得訂價和供貨情況

化驗

98%

折射率

n20/D 1.4632 (lit.)

mp

7.5 °C (lit.)

密度

1.294 g/mL at 25 °C (lit.)

SMILES 字串

FC(F)(F)c1ccccc1C#N

InChI

1S/C8H4F3N/c9-8(10,11)7-4-2-1-3-6(7)5-12/h1-4H

InChI 密鑰

SOZGHDCEWOLLHV-UHFFFAOYSA-N

一般說明

2-(Trifluoromethyl)benzonitrile reacts with tert-butyl acetate in the presence of sulfuric acid to give the corresponding N-tert-butyl amides[1].

應用

2-(Trifluoromethyl)benzonitrile was used in the synthesis of symmetrical N,N′-alkylidine bisamides[2].

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

水污染物質分類(WGK)

WGK 2

閃點(°F)

194.0 °F - closed cup

閃點(°C)

90 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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A convenient and efficient protocol for the synthesis of symmetrical N,N'-alkylidine bisamides by sulfamic acid under solvent-free conditions.
Selvam NP, et al.
Canadian Journal of Chemistry, 86(1), 32-38 (2008)
An efficient method for the conversion of aromatic and aliphatic nitriles to the corresponding N-tert-butyl amides: a modified Ritter reaction.
Reddy KL.
Tetrahedron Letters, 44(7), 1453-1455 (2003)
Megumi Morimoto et al.
PloS one, 12(12), e0189480-e0189480 (2017-12-08)
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators (SARMs) are considered as therapeutic targets.
Nobuyuki Ishikura et al.
International journal of oncology, 46(4), 1560-1572 (2015-01-31)
Resistance of prostate cancer to castration is currently an unavoidable problem. The major mechanisms underlying such resistance are androgen receptor (AR) overexpression, androgen-independent activation of AR, and AR mutation. To address this problem, we developed an AR pure antagonist, CH5137291

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