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重要文件

220027

Sigma-Aldrich

3-吲哚丙酸

ReagentPlus®, 99%

同義詞:

3-(3-吲哚基)丙酸, IPA, NSC 3252, NSC 47831, 吲哚-3-丙酸

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About This Item

經驗公式(希爾表示法):
C11H11NO2
CAS號碼:
分子量::
189.21
Beilstein:
147733
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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品質等級

產品線

ReagentPlus®

化驗

99%

形狀

powder

mp

134-135 °C (lit.)

溶解度

ethanol: soluble 50 mg/mL, clear, yellow to orange

官能基

carboxylic acid

SMILES 字串

OC(=O)CCc1c[nH]c2ccccc12

InChI

1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)

InChI 密鑰

GOLXRNDWAUTYKT-UHFFFAOYSA-N

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一般說明

3-吲哚丙酸是错误折叠的β-淀粉样蛋白(Abeta)聚集的一种有效抑制剂[1]。通过三组分一锅法进行3-吲哚丙酸的组装已被报道[2]

應用

反应物用于制备:
  • 独脚金内酯的荧光类似物
  • 抗肿瘤剂
  • 黑皮质素受体配体
  • 免疫抑制剂
  • 丙肝病毒抑制剂
  • 组胺H4受体激动剂
  • NR2B/NMDA受体拮抗剂
  • CB1拮抗剂用于治疗肥胖症免疫抑制剂
  • 抗细菌剂
  • TGF-β受体结合抑制剂

法律資訊

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Xun Cheng et al.
Analytical chemistry, 77(21), 7012-7015 (2005-11-01)
Alzheimer's disease is the most common cause of the loss of cognitive function among the elderly, and the aggregation and deposition of misfolded beta-amyloid protein (Abeta) contribute to this progressive central nervous system decline. Therefore, compounds that inhibit or even
Mauro F A Adamo et al.
Organic letters, 9(2), 303-305 (2007-01-16)
A three-component one-pot procedure (3-MC) was developed to assemble 3-indolepropionic acids from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography. [reaction: see text].
Burkhard Poeggeler et al.
PloS one, 5(4), e10206-e10206 (2010-04-28)
Aging is a multi-factorial process, however, it is generally accepted that reactive oxygen species (ROS) are significant contributors. Mitochondria are important players in the aging process because they produce most of the cellular ROS. Despite the strength of the free-radical
K L Borden et al.
European journal of biochemistry, 202(2), 459-470 (1991-12-05)
The antirepressor indole 3-propanoate has been shown by X-ray crystallography to bind in a different orientation compared with the natural corepressor for the tryp repressor, L-tryptophan (Lawson, C.L. & Sigler, P. B. (1988) Nature 333, 869-871). This suggests a simple
Stéphanie Ortial et al.
Journal of medicinal chemistry, 49(9), 2812-2820 (2006-04-28)
The use of classical antioxidants is limited by their low bioavailabilities, and therefore, high doses are usually required to display significant protective activity. In a recent article (J. Med. Chem. 2003, 46, 5230) we showed that the ability of the

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