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210145

Sigma-Aldrich

2,2-二甲基-1,3-二噁烷-4,6-二酮

2,2-Dimethyl-1,3-dioxane-4,6-dione

98%

同義詞:

丙二酸亚异丙酯, 丙二酸环亚异丙酯, 米氏酸

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About This Item

經驗公式（希爾表示法）:
C6H8O4
CAS號碼:
2033-24-1
分子量：:
144.13
Beilstein:
117310
EC號碼:
217-992-8
MDL號碼:
MFCD00006638
分類程式碼代碼:
12352100
PubChem物質ID:
24852618
NACRES:
NA.22
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化驗

98%

形狀

solid

mp

92-96 °C (lit.)

溶解度

dioxane: soluble 5%, clear to very slightly hazy, colorless to faintly yellow

官能基

ester
ketal

儲存溫度

2-8°C

SMILES 字串

CC1(C)OC(=O)CC(=O)O1

InChI

1S/C6H8O4/c1-6(2)9-4(7)3-5(8)10-6/h3H2,1-2H3

InChI 密鑰

GXHFUVWIGNLZSC-UHFFFAOYSA-N

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相關類別

一般說明

2,2-二甲基-1,3-二恶烷-4,6-二酮（米氏′酸）广泛用于有机合成，特别是对于多种CC键形成，因为它具有足够的酸性 (pKa 4.83) 和空间刚性[1]。醛与米氏′酸之间的Knoevenagel缩合反应在离子液体中加速。[2]

米氏′酸被用作合成杂环的有价值的起始原料和有机合成反应的中间体。[3][4]

應用

2,2-二甲基-1,3-二恶烷-4,6-二酮用于合成：
  • 大环 β-酮内酯[5]
  • 4-吡啶基取代的杂环[6]
  • 2-取代吲哚[7]
  • 异秦皮啶。[8]

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number
BCCH9274
STBJ3104
STBF4868V
STBG8233
STBD6952V

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文章

Knoevenagel 冷凝反應

Knoevenagel Condensation 是以 Emil Knoevenagel 命名的有機反應。它是典型的 C-C 鍵形成反應，也是 Aldol Condensation 的改良。

Knoevenagel Condensation Reaction

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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