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Merck
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重要文件

194719

Sigma-Aldrich

长春胺

98%

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About This Item

經驗公式(希爾表示法):
C21H26N2O3
CAS號碼:
分子量::
354.44
EC號碼:
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22
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化驗

98%

光學活性

[α]23/D +42.8°, c = 1 in pyridine

mp

232 °C (dec.) (lit.)

SMILES 字串

CC[C@@]12CCCN3CCc4c(C13)n(c5ccccc45)[C@](O)(C2)C(=O)OC

InChI

1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1

InChI 密鑰

RXPRRQLKFXBCSJ-GIVPXCGWSA-N

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應用

Vincamine can be used as a starting material to synthesize:
  • Vincamine acid, which is employed as a precursor in the synthesis of vinpocetine by dehydration and esterification using sulfuric acid.[1]
  • Apovincamine using iron(III) perchlorate.[2]
  • (-)-Criocerine via one-step iodination reaction.[3]

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Adám Vas et al.
Medicinal research reviews, 25(6), 737-757 (2005-09-15)
The Apocynaceae plant family contains a great number of so called eburnamine-vincamine alkaloids. Quite a few of these alkaloids exert varied pharmacological activities on the cell multiplication, cardiovascular system, and brain functions. Many derivatives were also synthesized to find pharmacologically
S Caccamese et al.
Journal of chromatography. A, 893(1), 47-54 (2000-10-24)
The four enantiomeric pairs of vincamine group alkaloids were separated by HPLC using Chiralpak AD as chiral stationary phase (CSP) and various n-hexane-2-propanol and n-hexane-ethanol mobile phases. (+)-cis-Vincamine, which is used in pharmaceutical preparations, is eluted much faster than its
K Cambon et al.
Neuroscience, 171(3), 840-851 (2010-10-07)
The Balb/c strain and the C57BL/6 strain show constitutive differences for tyrosine hydroxylase expression, and noradrenaline (NA) prefrontal transmission. Male mice of these strains also show striking differences in social interaction behaviors, with an increased aggressiveness for the Balb/c strain.
Iron (III) Perchlorate-A Novel Reagent for the Conversion of Vincamine, Criocerine and 18-Iodocriocerine to Apovincamine: A New Method.
Lakshmi V and Bhaduri AP
ChemInform, 25(18) (1994)
Mazák Károly et al.
Journal of chromatography. A, 996(1-2), 195-203 (2003-07-02)
A reversed-phase thin-layer chromatographic method was developed and applied to quantitate the lipophilicity of sparingly water-soluble eburnane alkaloids of therapeutic interest. Our method development included calibration, optimization and validation procedures, using also sets of auxiliary compounds. The log P(TLC) values

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