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重要文件

193291

Sigma-Aldrich

2-氯嘧啶

95%

同義詞:

2-氯-1,3-嘧啶, 嘧啶-2-酰氯

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About This Item

經驗公式(希爾表示法):
C4H3ClN2
CAS號碼:
分子量::
114.53
Beilstein:
107171
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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品質等級

化驗

95%

形狀

crystals

bp

75-76 °C/10 mmHg (lit.)

mp

63-66 °C (lit.)

官能基

chloro

SMILES 字串

Clc1ncccn1

InChI

1S/C4H3ClN2/c5-4-6-2-1-3-7-4/h1-3H

InChI 密鑰

UNCQVRBWJWWJBF-UHFFFAOYSA-N

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一般說明

2-氯嘧啶可与芳基卤化物发生经钴催化的交叉偶联反应[1]

應用

2-氯嘧啶可用于合成:
  • (2-(嘧啶-2-基)乙氧基)烷烃[2]
  • 4′-(1,1′-(5-(2-甲氧基苯氧基)-[2,2′-联嘧啶基]-4,6-二基)(1H-吡唑-3,1-二基))二苯胺荧光染料,可用作蛋白质测定的生物传感器[3]
  • 顺式-和 反式-氢化吡咯并[2,3]吡啶衍生物[4]
  • 2-氨基-4-杂芳基嘧啶[5]

其他說明

残留物为 2-羟基嘧啶

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

208.4 °F - closed cup

閃點(°C)

98 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Matthew G Bursavich et al.
Organic letters, 7(19), 4113-4116 (2005-09-09)
[reaction: see text] An expedient synthesis of diverse 2-amino-4-heteroarylpyrimidines via a 2-chloropyrimidine intermediate is described. A series of potentially biologically active analogues have been synthesized in two parallel steps to afford focused arrays.
Vangavaragu Jhansi Rani et al.
Archiv der Pharmazie, 345(8), 663-669 (2012-05-18)
The pyrimidine nucleus is an important component of nucleic acids (DNA and RNA) and vitamins (B(2) and folic acid). It is evident from the literature that pyrimidine derivatives possess a wide spectrum of biological activities such as antioxidant, anticancer, antibacterial
Igor Goljer et al.
Chirality, 21(7), 681-691 (2008-09-17)
Reaction of (S)- or (R)-3-aminoquinuclidine with 2-chloropyrimidine or 2-bromopyrimidine led to an unexpected formation of both cis- and trans-octahydropyrrolo [2,3]pyridine derivatives. A single-step synthesis of two of the four stereoisomers of these octahydropyrrolo[2,3]pyridine derivatives provides a convenient way of generating
Vikas S Padalkar et al.
Chemistry Central journal, 5, 72-72 (2011-11-10)
Fluorescent dyes with biocompatible functional group and good fluorescence behavior are used as biosensor for monitoring different biological processes as well as detection of protein assay. All reported fluorophore used as sensors are having high selectivity and sensitivity but till
Carina Sollert et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(14), 5380-5386 (2015-02-18)
The Ru-catalysed C2-H arylation of indoles and pyrroles by using boronic acids under oxidative conditions is reported. This reaction can be applied to tryptophan derivatives and tolerates a wide range of functional groups on both coupling partners, including bromides and

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