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重要文件

132888

Sigma-Aldrich

2-氯-4′-氟苯乙酮

99%

同義詞:

ω-氯-4-氟苯乙酮, 2-氯-4'-氟乙酰苯

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About This Item

線性公式:
FC6H4COCH2Cl
CAS號碼:
分子量::
172.58
Beilstein:
637860
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
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化驗

99%

形狀

solid

mp

47-50 °C (lit.)

官能基

chloro
fluoro
ketone

SMILES 字串

Fc1ccc(cc1)C(=O)CCl

InChI

1S/C8H6ClFO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2

InChI 密鑰

UJZWJOQRSMOFMA-UHFFFAOYSA-N

基因資訊

human ... PTPN6(5777)

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一般說明

2-Chloro-4′-fluoroacetophenone on condensation with N-methyl-4-(methylthio)benzamidine yields 1-methyl-2-(4-methylthio)phenyl-4-(4-fluoro)phenylimidazole[1].

應用

2-Chloro-4′-fluoroacetophenone was used in the synthesis of S-(phenacyl)glutathiones[2] and 2-[3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-(4-fluorophenyl)ethanone[3].

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

230.0 °F - closed cup

閃點(°C)

110 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Allergic contact dermatitis from 3-(alpha-methoxy) methylenebenzofuran-2(3H)-one (MBF) and alpha-chloro-4-fluoroacetophenone (CFAP) in chemical process workers.
M J Boffa et al.
Contact dermatitis, 34(6), 434-435 (1996-06-01)
Donald M N Sikazwe et al.
Bioorganic & medicinal chemistry, 17(4), 1716-1723 (2009-01-22)
Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous reports indicates that arylalkyl substituents can improve the potency and selectivity of the binding affinity at D(2)-like
Philip G Board et al.
Chemical research in toxicology, 20(1), 149-154 (2007-01-18)
S-(Phenacyl)glutathione reductase (SPG-R) plays a significant role in the biotransformation of reactive alpha-haloketones to nontoxic acetophenones. Comparison of the apparent subunit size, amino acid composition, and catalysis of the reduction of S-(phenacyl)glutathiones indicated that a previously described rat SPG-R (Kitada
2, 4, 5-Triarylimidazole inhibitors of IL-1 biosynthesis.
Gallagher TF, et al.
Bioorganic & Medicinal Chemistry Letters, 5(11), 1171-1176 (1995)
Justin D Smith et al.
Nature communications, 10(1), 1837-1837 (2019-04-25)
Photocatalytic polymers offer an alternative to prevailing organometallics and nanomaterials, and they may benefit from polymer-mediated catalytic and material enhancements. MPC-1, a polymer photoredox catalyst reported herein, exhibits enhanced catalytic activity arising from charge transfer states (CTSs) between its two

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