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Merck

CHRNA4

cholinergic receptor, nicotinic, alpha 4 (neuronal)

同義詞:
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
物種:
UniProtKB ID:
基因 ID:
  • Human(1137) Summary: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
  • Mouse(11438) cholinergic receptor, nicotinic, alpha polypeptide 4
  • Rat(25590) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • chicken(395606) cholinergic receptor, nicotinic, alpha 4
  • Domestic Rabbit(100345481) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • sheep(101118889) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • naked mole-rat(101714448) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • domestic guinea pig(100716877) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • cow(537251) cholinergic receptor, nicotinic, alpha 4
  • Zebrafish(556619) cholinergic receptor, nicotinic, alpha 4
  • Horse(100146784) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • domestic cat(101101300) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • dog(485972) cholinergic receptor, nicotinic, alpha 4 (neuronal)

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Small Molecule - Agonist

產品編號
描述
物種
S(−)-尼古丁 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
物種
human
(-)-尼古丁 半硫酸盐, ≥95% (TLC), ~35 % (w/v) in H2O (based on free base),
物種
human
(−)-尼古丁, PESTANAL®, analytical standard,
物種
human
(±)-尼古丁, ≥99% (TLC), liquid,
物種
human, rat
卡巴胆碱, ≥98% (titration), crystalline,
物種
human, mouse, rat

Small Molecule - Antagonist

產品編號
描述
物種
麦斯明, ≥98%,
物種
rat
(±)-原烟碱, ≥98% (TLC), liquid,
物種
mouse, rat
金雀花碱, ≥99%, powder,
物種
rat
(±)-尼古丁, ≥99% (TLC), liquid,
物種
human, rat
卡巴胆碱, ≥98% (titration), crystalline,
物種
human, mouse, rat

Antibodies

產品編號
描述
物種活性
應用
抗烟碱型乙酰胆碱受体α4抗体, from rabbit, purified by affinity chromatography,
物種活性
human, mouse, rat
應用
western blot

Small Molecule - Blocker

產品編號
描述
物種
四乙基氯化铵, ≥98% (titration),
物種
human
溴化已烷双胺, ,
物種
human
氯化六甲铵, solid (hygroscopic),
物種
human
犬尿喹啉酸, ≥98%,
物種
rat, human