A1075

Amyloid β Protein Fragment 1-40

≥90% (HPLC), powder

• Synonym(s): Aβ40
• Empirical Formula (Hill Notation): C₁₉₄H₂₉₅N₅₃O₅₈S
• CAS Number: 131438-79-4
• Molecular Weight: 4329.80
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00130509
• Form: powder
• Assay: ≥90% (HPLC)

Properties

• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: powder
• color: white
• solubility: 1% acetic acid: 1 mg/mL, saline: insoluble
• UniProt accession no.: P05067
• storage temp.: −20°C
• Gene Information: human ... APP(351)

Description

General description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.

Application

Amyloid β Protein Fragment 1-40 has been used:

• in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies
• as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma
• as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.

Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels.

Preparation Note

For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)