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G6793

Sigma-Aldrich

GW7647

≥98% (HPLC)

Sinónimos:

2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)­phenyl­thio)-2-methyl­propionic acid

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About This Item

Fórmula empírica (notación de Hill):
C29H46N2O3S
Número de CAS:
265129-71-3
Peso molecular:
502.75
Número MDL:
MFCD06798379
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278790
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

color

white

solubilidad

DMSO: soluble 16 mg/mL
H2O: insoluble

cadena SMILES

CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O

InChI

1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)

Clave InChI

PKNYXWMTHFMHKD-UHFFFAOYSA-N

Información sobre el gen

human ... PPARA(5465)

Aplicación

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:
  • in defatting medium to treat primary human hepatocytes
  • to test its effect on the glycolytic function in cardiomyocytes
  • to test its effect on infant mouse heart
  • in breast cancer MDA-MB-231 cells to activate PPARs

Acciones bioquímicas o fisiológicas

GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation. Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.
Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.

Características y beneficios

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información legal

Sold for research purposes only under agreement from Glaxo­Smith­Kline

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000381976
0000381976
0000284378
0000178596
0000165483

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Jun Zhang et al.
Oncotarget, 8(13), 20766-20783 (2017-02-12)
Peroxisome proliferators-activated receptors (PPARα, γ and δ) are potentially effective targets for Type 2 diabetes mellitus therapy. The severe effects of known glitazones and the successfully approved agents (saroglitazar and lobeglitazone) motivated us to study novelly potent PPARs drugs with
Yanjie Cheng et al.
Molecular therapy. Nucleic acids, 9, 195-206 (2017-12-17)
Widely varied compounds, including certain plasticizers, hypolipidemic drugs (e.g., ciprofibrate, fenofibrate, WY-14643, and clofibrate), agrochemicals, and environmental pollutants, are peroxisome proliferators (PPs). Appropriate dose of PPs causes a moderate increase in the number and size of peroxisomes and the expression
Shinya Okishio et al.
Scientific reports, 10(1), 19578-19578 (2020-11-13)
We explored the beneficial effects of GW7647, a peroxisome proliferator activated receptor α (PPARα) agonist, and metformin, an anti-diabetic drug on an advanced nonalcoholic steatohepatitis (NASH) model in rodents and investigated the possible mechanisms involved. Mice were fed control chow
Sriram Ramanan et al.
Free radical biology & medicine, 45(12), 1695-1704 (2008-10-15)
Whole-brain irradiation (WBI) can lead to cognitive impairment several months to years after irradiation. Studies on rodents have shown a rapid and sustained increase in activated microglia (brain macrophages) following brain irradiation, contributing to a chronic inflammatory response and a
Luisa Vergori et al.
Stem cells translational medicine, 7(1), 135-145 (2017-10-29)
Metabolic pathologies such as diabetes and obesity are associated with decreased level of circulating and bone marrow (BM)-derived endothelial progenitor cells (EPCs). It is known that activation of peroxisome proliferator-activated receptor alpha (PPARα) may stimulate cell differentiation. In addition, microparticles
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