G3046

GDF-15 human

• Sinónimos: Growth Differentiation Factor 15 human, MIC-1, Macrophage inhibitory cyotkine-1
• Número de CAS: 1821355-80-9
• Código UNSPSC: 12352202
• NACRES: NA.26

Propiedades

• origen biológico: human
• Nivel de calidad: 100
• recombinante: expressed in CHO cells
• Ensayo: >97% (visualized with silver stain, SDS-PAGE)
• Formulario: lyophilized powder
• mol peso: dimer 13 kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag)
• técnicas: cell culture | mammalian: suitable
• impurezas: endotoxin, tested
• Nº de acceso UniProt: Q99988
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... GDF15(9518)

Descripción

Descripción general

Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.² It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1.

Aplicación

Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.

Acciones bioquímicas o fisiológicas

Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.

Forma física

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of GDF-15.

Nota de análisis

Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable