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399275

Sigma-Aldrich

Nω-Hydroxy-nor-L-arginine, Diacetate Salt

A potent, selective, competitive, and high affinity inhibitor of arginase.

Sinónimos:

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

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About This Item

Fórmula empírica (notación de Hill):
C5H12N4O3 · 2C2H4O2
Número de CAS:
189302-40-7
Peso molecular:
296.28
Número MDL:
MFCD01318777
Código UNSPSC:
12352209
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥97% (TLC)

Formulario

solid

potencia

2 μM IC50

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
desiccated (hygroscopic)

color

off-white

solubilidad

water: 50 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

−20°C

cadena SMILES

N(O)\C(=N\CC[C@H](N)C(=O)O)\N.OC(=O)C.OC(=O)C

Clave InChI

PQFYTZJPYBMTCT-QTNFYWBSSA-N

Descripción general

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Acciones bioquímicas o fisiológicas

Primary Target
arginase from rat liver
Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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