N5501

N_ω-Nitro-L-arginine

≥98% (TLC)

• Sinónimos: L-NNA, N⁵-(Nitroamidino)-L-2,5-diaminopentanoic acid, N^G-NO₂-L-Arg
• Fórmula empírica (notación de Hill): C₆H₁₃N₅O₄
• Número de CAS: 2149-70-4
• Peso molecular: 219.20
• Beilstein: 1728914
• Número CE: 218-418-9
• Número MDL: MFCD00007033
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24278010
• NACRES: NA.77

Propiedades

• origen biológico: synthetic
• Ensayo: ≥98% (TLC)
• Formulario: powder
• mp: 257 °C
• solubilidad: 1 M HCl: 50 mg/mL, clear, colorless to faintly yellow
• cadena SMILES: N[C@@H](CCCNC(=N)N[N+]([O-])=O)C(O)=O
• InChI: 1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1
• Clave InChI: MRAUNPAHJZDYCK-BYPYZUCNSA-N
• Información sobre el gen: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Grin2a(24409) , Nos1(24598)

Descripción

Aplicación

N_ω-Nitro-L-arginine has been used:

• as nitric oxide synthase (NOS) inhibitor, to measure the release of nitric oxide (NO) derivatives in cytochrome c reduction assay
• to pretreat fiber bundles for contractile studies
• as NOS inhibitor to characterize the generation of NO in Taxus yunnanensis cells
• as an irreversible inhibitor of the neuronal NO synthase (nNOS) to preincubate swimbladder preparations

Acciones bioquímicas o fisiológicas

Irreversible inhibitor of constitutive nitric oxide synthase (nNOS) and a reversible inhibitor of inducible nitric oxide synthase (iNOS).

N_ω-Nitro-L-arginine/L-NNA helps to reduce the levels of cortical hyperemia and brain cGMP occurring due to hypercapnia.

Características y beneficios

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)