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Key Documents

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H7278

Sigma-Aldrich

NG-Hydroxy-L-arginine acetate salt

Sinónimos:

NOHA acetate salt

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About This Item

Fórmula empírica (notación de Hill):
C6H14N4O3 · C2H4O2
Número de CAS:
53598-01-9
Peso molecular:
250.25
MDL number:
MFCD00216150
UNSPSC Code:
12352209
PubChem Substance ID:
24278471
NACRES:
NA.77

assay

≥98% (TLC)

form

powder

mp

204 °C

solubility

acetic acid: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

CC(O)=O.N[C@@H](CCCNC(=N)NO)C(O)=O

InChI

1S/C6H14N4O3.C2H4O2/c7-4(5(11)12)2-1-3-9-6(8)10-13;1-2(3)4/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10);1H3,(H,3,4)/t4-;/m0./s1

InChI key

VYMCYRPQICLHKC-WCCKRBBISA-N

Biochem/physiol Actions

Intermediate in the conversion of arginine to NO and citrulline by NO synthase.
NG-Hydroxy-L-arginine acts as a physiological inhibitor of arginase.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The inhibition of arginase by N?-hydroxy-L-arginine controls the growth of Leishmania inside macrophages
Iniesta V, et al.
The Journal of Experimental Medicine, 193(6), 777-784 (2001)
T Pera et al.
The Journal of pharmacology and experimental therapeutics, 349(2), 229-238 (2014-02-25)
Airway inflammation and remodeling are major features of chronic obstructive pulmonary disease (COPD), whereas pulmonary hypertension is a common comorbidity associated with a poor disease prognosis. Recent studies in animal models have indicated that increased arginase activity contributes to features
Alexander Bollenbach et al.
Analytical biochemistry, 577, 59-66 (2019-04-28)
l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT). AGAT also catalyzes the formation of guanidinoacetate (GAA) from Arg and glycine (Gly). GAA is converted to creatine (N-methyl guanidinoacetate) by guanidinoacetate N-methyl-transferase (GAMT). Low circulating
K L Campos et al.
The Journal of biological chemistry, 270(4), 1721-1728 (1995-01-27)
The nitric oxide synthase-catalyzed conversion of L-arginine to L-citrulline and nitric oxide is known to be the sum of two partial reactions: oxygenation of arginine to N-hydroxyarginine, followed by oxygenation of N-hydroxyarginine to citrulline and nitric oxide. Whereas the conversion
P Klatt et al.
The Journal of biological chemistry, 268(20), 14781-14787 (1993-07-15)
Brain NO (nitric oxide) synthase contains FAD, FMN, heme, and tetrahydrobiopterin as prosthetic groups and represents a multi-functional oxidoreductase catalyzing oxidation of L-arginine to NO and L-citrulline, formation of H2O2, and reduction of cytochrome c. We show that substrate analogues
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