U8881
UCL 1684 ditrifluoroacetate hydrate
别名:
6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
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所有图片(1)
About This Item
线性分子式:
(C34H30N4)2+ · (C2F3O2-)2 · xH2O
CAS号:
分子量:
720.66 (anhydrous basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
价格与库存信息目前不能提供
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颜色
white to off-white
溶解性
DMSO: 10 mg/mL
SMILES字符串
[H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7
InChI
1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;
InChI key
YROHEYZVNZITJN-DDVHGCDCSA-N
应用
UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair[1]. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries[2].
生化/生理作用
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
制备说明
UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
UCL 1684: a potent blocker of Ca2+-activated K+ channels in rat adrenal chromaffin cells in culture
Dunn PM
European Journal of Pharmacology, 368(1), 119-123 (1999)
Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion
Zhang M, et al.
The Journal of General Physiology, 126(4), 353-363 (2005)
P M Dunn
European journal of pharmacology, 368(1), 119-123 (1999-03-30)
The novel K+ channel blocker 6,10-diaza-3(1,3)8,(1,4)-dibenzena-1,5(1,4)-diquinolinacy clodecaphane (UCL 1684) has been tested for its ability to inhibit Ca2+ -activated K+ currents in cultured rat chromaffin cells. Low nanomolar concentrations of UCL 1684 produced a rapid and reversible inhibition of the
Crucial role of a shared extracellular loop in apamin sensitivity and maintenance of pore shape of small-conductance calcium-activated potassium (SK) channels
Weatherall KL, et al.
Proceedings of the National Academy of Sciences of the USA, 108(45), 18494-18499 (2011)
Chao Fan Liang et al.
The Journal of pharmacology and experimental therapeutics, 334(1), 223-231 (2010-03-25)
The present experiments investigated whether endothelium-derived mediators modulate the effect of natriuretic peptides in porcine coronary arteries. Rings with and without endothelium were suspended in organ chambers for isometric tension recording. Concentration-relaxation curves to C-type natriuretic peptide (CNP) and atrial
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