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U104

Sigma-Aldrich

UK 14,304

别名:

5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine

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5 MG
$98.10
25 MG
$358.00
100 MG
$1,160.00

$98.10

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5 MG
$98.10
25 MG
$358.00
100 MG
$1,160.00

About This Item

经验公式（希尔记法）:
C11H10BrN5
CAS号:
59803-98-4
分子量:
292.13
MDL编号:
MFCD00153878
UNSPSC代码:
12352200
PubChem化学物质编号:
24277812
NACRES:
NA.77

$98.10

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质量水平

100

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
DMSO: >6.5 mg/mL
ethanol: <8 mg/mL (warm)
H2O: insoluble

SMILES字符串

Brc1c(NC2=NCCN2)ccc3nccnc13

InChI

1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)

InChI key

XYLJNLCSTIOKRM-UHFFFAOYSA-N

基因信息

human ... ADRA1A(148) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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应用

UK 14,304 已用于肠肌间神经元，以研究 R 型钙电流的抑制 [1]。UK 14,304 也曾用于免疫荧光显微术分析 [2]。
在心外膜冠状动脉培养中，UK 14,304 已用于激活细胞外信号调节激酶 (ERK)[3]

生化/生理作用

UK 14,304 是 α2-肾上腺素受体激动剂。[4]UK 14,304 抑制激素敏感型脂肪酶 (HSL) 活性并抑制脂肪组织中的脂肪生成。[5]

特点和优势

该化合物在受体分类和信号转导手册中α2-肾上腺素能受体页面中进行了详细介绍。想要浏览手册的其他页面， 请单击此处。

制备说明

UK 14,304 可溶于 45%（w/v）aq 2-羟丙基-β--环糊精（<0.8 mg/mL), DMSO (> 6.5 mg/mL）和乙醇（<8 mg/mL）。但它不溶于水。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000360993
0000360994
0000360994
0000360993
0000215832

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Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
Jensen BC, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 382(5-6), 475-482 (2010)
Brittany J Carr et al.
Clinical & experimental optometry, 102(4), 418-425 (2019-01-31)
The putative myopia-controlling receptor is thought to be muscarinic acetylcholine receptor subtype M4 , because mamba toxin-3 can inhibit form-deprivation myopia in chicks at a far lower concentration than atropine. However, mamba toxin-3 is equally potent at the human α1A
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.
Francis H, et al.
American Journal of Physiology. Cell Physiology, 293(4), C1252-C1262 (2007)
Effects of acute and chronic ethanol administration on the response of mouse adipose tissue hormone-sensitive lipase to alpha2-adrenoceptor activation by UK 14304.
Shih MF and Taberner PV
Alcohol and Alcoholism (Oxford, Oxfordshire), 36(5), 381-387 (2001)
Kenric Rui-Pin Fan et al.
Acta ophthalmologica, 97(6), e827-e832 (2019-03-28)
To investigate the neuroprotective effect of Copolymer-1 (Cop-1) in patients with acute primary angle closure (APAC) in a randomized double-masked controlled trial. After initial medical management, APAC patients were randomized to receive either subcutaneous Cop-1 or placebo within 24 hr and
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